ArticleMolecules (Basel, Switzerland)2019
Sterile and Dual-Porous Aerogels Scaffolds Obtained through a Multistep Supercritical CO₂-Based Approach.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
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- Processes of Obtaining Nanostructured Materialswith a Hierarchical Porous Structure on the Example of Alginate Aerogels.Gels (Basel, Switzerland) · 2024Article
- Biopolymer-Based Biomimetic Aerogel for Biomedical Applications.Biomimetics (Basel, Switzerland) · 2024Review
- Chemical Modifications of Normal and Waxy Potato Starches Affect Functional Properties of Aerogels.Gels (Basel, Switzerland) · 2022Article
- Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy.Gels (Basel, Switzerland) · 2022Article
- Supercritical COThe Science of the total environment · 2022Article
- 3D-Printed, Dual Crosslinked and Sterile Aerogel Scaffolds for Bone Tissue Engineering.Polymers · 2022Article
- Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds.Molecules (Basel, Switzerland) · 2021Review
- Computational design of biopolymer aerogels and predictive modelling of their nanostructure and mechanical behaviour.Scientific reports · 2021Article
- Article
- Biorefinery Approach for Aerogels.Polymers · 2020Review
- Smart Porous Multi-Stimulus Polysaccharide-Based Biomaterials for Tissue Engineering.Molecules (Basel, Switzerland) · 2020Review
- Photocurable Methacrylate Derivatives of Polylactide: A Two-Stage Synthesis in Supercritical Carbon Dioxide and 3D Laser Structuring.Polymers · 2020Article
- New Trends in Bio-Based Aerogels.Pharmaceutics · 2020Review
- Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin.Polymers · 2020Article
- An Opinion Paper on Aerogels for Biomedical and Environmental Applications.Molecules (Basel, Switzerland) · 2019Article
- Design of Aerogels, Cryogels and Xerogels of Alginate: Effect of Molecular Weight, Gelation Conditions and Drying Method on Particles' Micromeritics.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Aerogels from natural polymers are endowed with attractive textural and biological properties for biomedical applications due to their high open mesoporosity, low density, and reduced toxicity. Nevertheless, the lack of macroporosity in the aerogel structure and of a sterilization method suitable for these materials restrict their use for regenerative medicine purposes and prompt the research on getting ready-to-implant dual (macro + meso)porous aerogels. In this work, zein, a family of proteins present in materials for tissue engineering, was evaluated as a sacrificial porogen to obtain macroporous starch aerogels. This approach was particularly advantageous since it could be integrated in the conventional aerogel processing method without extra leaching steps. Physicochemical, morphological, and mechanical characterization were performed to study the effect of porogen zein at various proportions (0:1, 1:2, and 1:1 zein:starch weight ratio) on the properties of the obtained starch-based aerogels. From a forward-looking perspective for its clinical application, a supercritical CO₂ sterilization treatment was implemented for these aerogels. The sterilization efficacy and the influence of the treatment on the aerogel final properties were evaluated mainly in terms of absence of microbial growth, cytocompatibility, as well as physicochemical, structural, and mechanical modifications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.