Evidence map›Paper›PMID 30823663›Full record

ArticleViruses2019

Genomics Analyses of GIV and GVI Noroviruses Reveal the Distinct Clustering of Human and Animal Viruses.

Lauren A Ford-Siltz, Lisa Mullis, Yasser M Sanad, Kentaro Tohma, Cara J Lepore, Marli Azevedo, Gabriel I Parra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lauren A Ford-SiltzDivision of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. lauren.siltz@fda.hhs.gov.
Lisa MullisDivision of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Lisa.Mullis@fda.hhs.gov.ORCID 0000-0003-1853-5807
Yasser M SanadDepartment of Agriculture, School of Agriculture, Fisheries, and Human Sciences, University of Arkansas, Pine Bluff, AR 71601, USA. sanad.1@osu.edu.ORCID 0000-0001-6008-5630
Kentaro TohmaDivision of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. kentaro.tohma@fda.hhs.gov.
Cara J LeporeDivision of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. caralepore@gmail.com.ORCID 0000-0001-9349-3155
Marli AzevedoDivision of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. marli.azevedo@fda.hhs.gov.
Gabriel I ParraDivision of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. gabriel.parra@fda.hhs.gov.ORCID 0000-0002-1102-4740
Center for Biologics Evaluation and Research · USNational Center for Toxicological Research · USNational Research Centre · EG

Funding

U.S. Food and Drug Administration Z01 BK 04012-01 LHV to G.I.P
6 · The paper itself

Abstract

Noroviruses are highly diverse viruses that are the major viral cause of acute gastroenteritis in humans. Although these viruses can infect multiple mammalian species, their potential for zoonosis is not well understood, especially within Genogroup IV (GIV), which contains viruses that infect humans, canines, and felines. The study of GIV viruses has been, in part, hindered by the limited number of complete genomes. Here, we developed a full-genome amplicon-based platform that facilitated the sequencing of canine noroviruses circulating in the United States. Eight novel nearly full-length canine norovirus genomes and two nearly complete VP1 sequences, including four GIV.2, three GVI.1, and three GVI.2 viruses, were successfully obtained. Only animal strains exhibited GVI/GIV chimeric viruses, demonstrating restrictions in norovirus recombination. Using genomic, phylogenetic, and structural analyses, we show that differences within the major capsid protein and the non-structural proteins of GIV and GVI noroviruses could potentially limit cross-species transmission between humans, canines, and felines.

Indexed as

Genome, ViralAnimalsCaliciviridae InfectionsCapsid ProteinsCatsCluster AnalysisDog DiseasesDogsFecesGastroenteritisGenomicsGenotypeHigh-Throughput Nucleotide SequencingHumansNorovirusPhylogenyCapsid ProteinsRNA, ViralViral Nonstructural Proteinscanine norovirusinter-species transmissionnorovirus

Identifiers

PMID30823663
PMCPMC6466045
OpenAlexW2917532524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.