Evidence map›Paper›PMID 30823659›Full record

ArticleLife (Basel, Switzerland)2019

Molecular Diversity Required for the Formation of Autocatalytic Sets.

Wim Hordijk, Mike Steel, Stuart A Kauffman

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Is the emergence of life and of agency expected?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  2. Bifurcations and phase transitions in the origins of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  3. Article
  4. Semigroup models for biochemical reaction networks.Journal of mathematical biology · 2023
    Article
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  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wim HordijkSmartAnalytiX.com, Lausanne, Switzerland. wim@worldwidewanderings.net.ORCID 0000-0002-0223-6194
Mike SteelBiomathematics Research Centre, University of Canterbury, Christchurch 8140, New Zealand. mike.steel@canterbury.ac.nz.
Stuart A KauffmanInstitute for Systems Biology, Seattle, WA 98109, USA. stukauffman@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systems chemistry deals with the design and study of complex chemical systems. However, such systems are often difficult to investigate experimentally. We provide an example of how theoretical and simulation-based studies can provide useful insights into the properties and dynamics of complex chemical systems, in particular of autocatalytic sets. We investigate the issue of the required molecular diversity for autocatalytic sets to exist in random polymer libraries. Given a fixed probability that an arbitrary polymer catalyzes the formation of other polymers, we calculate this required molecular diversity theoretically for two particular models of chemical reaction systems, and then verify these calculations by computer simulations. We also argue that these results could be relevant to an origin of life scenario proposed recently by Damer and Deamer.

Indexed as

autocatalytic setsorigin of liferandom graphssystems chemistry

Identifiers

PMID30823659
PMCPMC6462942

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.