Evidence map›Paper›PMID 30823658›Full record

ArticleInternational journal of molecular sciences2019

Loss of SR-BI Down-Regulates MITF and Suppresses Extracellular Vesicle Release in Human Melanoma.

Katharina Kinslechner, Birgit Schütz, Martina Pistek, Philipp Rapolter, Hans P Weitzenböck, Harald Hundsberger, Wolfgang Mikulits, Johannes Grillari, Clemens Röhrl, Markus Hengstschläger and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
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  5. [Research progress on the mechanism of wound skin dys- pigmentation after burns].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Katharina KinslechnerCenter for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. katharina.kinslechner@meduniwien.ac.at.ORCID 0000-0001-9944-9999
Birgit SchützCenter for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. birgit.schuetz@meduniwien.ac.at.
Martina PistekCenter for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. martina.pistek@gmx.net.
Philipp RapolterCenter for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. rapolter.philipp@gmx.at.
Hans P WeitzenböckMedical and Pharmaceutical Biotechnology, IMC University of Applied Sciences, 3500 Krems, Austria. hans.weitzenboeck@fh-krems.ac.at.
Harald HundsbergerMedical and Pharmaceutical Biotechnology, IMC University of Applied Sciences, 3500 Krems, Austria. harald.hundsberger@fh-krems.ac.at.
Wolfgang MikulitsDepartment of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria. wolfgang.mikulits@meduniwien.ac.at.ORCID 0000-0003-4612-7106
Johannes GrillariDepartment of Biotechnology, BOKU -University of Natural Resources and Life Sciences, 1190 Vienna, Austria. johannes.grillari@boku.ac.at.
Clemens RöhrlCenter for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. clemens.roehrl@meduniwien.ac.at.
Markus HengstschlägerCenter for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. markus.hengstschlaeger@meduniwien.ac.at.
Herbert StanglCenter for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. herbert.stangl@meduniwien.ac.at.ORCID 0000-0002-7288-7320
Mario MikulaCenter for Pathobiochemistry and Genetics, Medical University of Vienna, 1090 Vienna, Austria. mario.mikula@meduniwien.ac.at.ORCID 0000-0001-5782-0681
Medical University of Vienna · ATIMC University of Applied Sciences Krems · ATBOKU University · ATComprehensive Cancer Center Vienna · AT

Funding

Austrian Science Fund FWF P 25336Austrian Science Fund FWF P 31720
6 · The paper itself

Abstract

Melanoma is a skin tumor with a high tendency for metastasis and thus is one of the deadliest cancers worldwide. Here, we investigated the expression of the scavenger receptor class B type 1 (SR-BI), a high-density lipoprotein (HDL) receptor, and tested for its role in melanoma pigmentation as well as extracellular vesicle release. We first analyzed the expression of

Indexed as

Cell Line, TumorDown-RegulationExtracellular VesiclesGene Expression Regulation, NeoplasticHumansMelanomaMicrophthalmia-Associated Transcription FactorProto-Oncogene Masrab GTP-Binding ProteinsScavenger Receptors, Class BSynaptosomal-Associated Protein 25Vesicular Transport ProteinsMAS1 protein, humanMicrophthalmia-Associated Transcription FactorMITF protein, humanProto-Oncogene Masrab GTP-Binding ProteinsSCARB1 protein, humanScavenger Receptors, Class BSNAP25 protein, humanSynaptosomal-Associated Protein 25Vesicular Transport ProteinsVps25 protein, humancMETextracellular vesiclesmelanoma metastasispigmentationSCARB1secretory pathway

Identifiers

PMID30823658
PMCPMC6429474
OpenAlexW2920732951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.