ArticleMolecules (Basel, Switzerland)2019
Engineering Peptide-Based Polyelectrolyte Complexes with Increased Hydrophobicity.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Developing Design Rules for Polyelectrolyte Complex Materials: Role of Polyelectrolyte Length, Charged Group, and Backbone.Macromolecules · 2026Article
- A molecular dynamics study of the structure and dynamics of screened polyelectrolyte complex materials.Soft matter · 2026Article
- Review
- Role of Charge Patterning and Hydrophobicity in Peptide-Based Complex Coacervates.Biomacromolecules · 2025Article
- Smart coacervate microdroplets: biomimetic design, material innovations, and emerging applications in biomacromolecule delivery.Bioactive materials · 2025Review
- Exploring the effects of excipients on complex coacervation.Journal of colloid and interface science · 2025Article
- Quantifying Hydrophilicity in Polyelectrolytes and Polyzwitterions.Macromolecules · 2025Article
- Effect of Degree of Substitution and Polymer Ratio on the Structure of Chitosan: Carboxymethyl Starch (Bio)Polyelectrolyte Complexes.Polymers · 2024Article
- Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment.Advanced healthcare materials · 2024Article
- Design Rules for the Sequestration of Viruses into Polypeptide Complex Coacervates.Biomacromolecules · 2024Article
- Self-Assembling Polypeptides in Complex Coacervation.Accounts of chemical research · 2024Article
- Moderated ionic bonding for water-free recyclable polyelectrolyte complex materials.Science advances · 2024Article
- Effect of Dynamically Arrested Domains on the Phase Behavior, Linear Viscoelasticity and Microstructure of Hyaluronic Acid - Chitosan Complex Coacervates.Macromolecules · 2023Article
- Advances in Self-Assembled Peptides as Drug Carriers.Pharmaceutics · 2023Review
- Polyelectrolyte Chondroitin Sulfate Microgels as a Carrier Material for Rosmarinic Acid and Their Antioxidant Ability.Polymers · 2022Article
- DNA dynamics in complex coacervate droplets and micelles.Soft matter · 2022Article
- Peptide-based coacervates in therapeutic applications.Frontiers in bioengineering and biotechnology · 2022Review
- Complex Coacervation of Polymerized Ionic Liquids in Non-aqueous Solvents.ACS polymers Au · 2021Article
- Polyelectrolyte Complex Coacervation across a Broad Range of Charge Densities.Macromolecules · 2021Article
- Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyelectrolyte complexation is a versatile platform for the design of self-assembled materials. Here we use rational design to create ionic hydrophobically-patterned peptides that allow us to precisely explore the role of hydrophobicity on electrostatic self-assembly. Polycations and polyanions were designed and synthesized with an alternating sequence of d- and l-chiral patterns of lysine or glutamic acid with either glycine, alanine or leucine due to their increasing hydrophobicity index, respectively. Two motifs were considered for the oppositely charged patterned peptides; one with equal residues of charged and uncharged amino acids and the other with increased charge density. Mass spectroscopy, circular dichroism, H- and F-NMR spectroscopy were used to characterize the polypeptides. Polyelectrolyte complexes (PECs) formed using the sequences were characterized using turbidity measurements, optical microscopy and infrared spectroscopy. Our results show that the critical salt concentration, a key measure of PEC stability, increased with both increasing charge density as well as hydrophobicity. Furthermore, by increasing the hydrophobicity, the amount of PEC formed increased with temperature, contrary to purely ionic PECs. Lastly, we assessed the encapsulation behavior of these materials using a hydrophobic dye. Concluding that encapsulation efficiency increased with hydrophobic content of the complexes providing insight for future work on the application of these materials for drug delivery.
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Registered trials
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