Evidence map›Paper›PMID 30823632›Full record

ArticleNutrients2019

Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans.

Ryan K Perkins, Edwin R Miranda, Kristian Karstoft, Paul J Beisswenger, Thomas P J Solomon, Jacob M Haus

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  13. Advanced Glycation End Products and Inflammatory Cytokine Profiles in Maintenance Hemodialysis Patients After the Ingestion of a Protein-Dense Meal.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2023
    Article
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  16. Plasma Levels of FreeNutrients · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Ryan K PerkinsSchool of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA. ryperkin@umich.edu.
Edwin R MirandaSchool of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA. edwinray@umich.edu.
Kristian KarstoftCentre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark. Kristian.Karstoft@regionh.dk.ORCID 0000-0002-6596-4199
Paul J BeisswengerGeisel School of Medicine, Dartmouth College, PreventAGE Healthcare, 16 Cavendish Court, Lebanon, NH 03766, USA. pjb@preventagehealthcare.com.
Thomas P J SolomonSchool of Sport, Exercise, and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, West Midlands B15 2TT, UK. t.solomon@bham.ac.uk.
Jacob M HausSchool of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA. jmhaus@umich.edu.ORCID 0000-0002-8048-2470
University of Michigan · USDartmouth College · USUniversity of Birmingham · GBUniversity of Copenhagen · DK

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Strategies and Functional Outcomes of Enhancing in Vivo Production of Soluble Rage IsoformsR01DK109948 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAUS, JACOB M · 2016 to 2020
$3.1M
European Foundation for the Study of Diabetes Paul Langerhans Program Grant (T.P.J.S)National Institutes of Health R01DK109948NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK109948
6 · The paper itself

Abstract

The purpose of this investigation was to evaluate the effects of experimental hyperglycemia on oxidative damage (OX), advanced glycation end products (AGEs), and the receptor for AGEs (RAGE) through an in vivo approach. Obese subjects (

Indexed as

BiomarkersChromatography, LiquidEnzyme-Linked Immunosorbent AssayFemaleGlucose Clamp TechniqueGlycation End Products, AdvancedHealthy VolunteersHumansHyperglycemiaMaleMiddle AgedObesityOxidative StressReceptor for Advanced Glycation End ProductsRenal EliminationTandem Mass SpectrometryBiomarkersesRAGE protein, humanGlycation End Products, AdvancedReceptor for Advanced Glycation End ProductshyperglycemiainflammationRAGEsoluble RAGE

Identifiers

PMID30823632
PMCPMC6471142
OpenAlexW2917311547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.