Evidence map›Paper›PMID 30823599›Full record

ArticleCancers2019

Developing a Prognostic Gene Panel of Epithelial Ovarian Cancer Patients by a Machine Learning Model.

Tzu-Pin Lu, Kuan-Ting Kuo, Ching-Hsuan Chen, Ming-Cheng Chang, Hsiu-Ping Lin, Yu-Hao Hu, Ying-Cheng Chiang, Wen-Fang Cheng, Chi-An Chen

Abstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  8. Artificial intelligence and machine learning in precision and genomic medicine.Medical oncology (Northwood, London, England) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tzu-Pin LuInstitute of Epidemiology and Preventive Medicine, Department of Public Health, National Taiwan University, Taipei 10055, Taiwan. tplu@ntu.edu.tw.
Kuan-Ting KuoDepartment of Pathology, College of Medicine, National Taiwan University, Taipei 10002, Taiwan. pathologykimo@gmail.com.
Ching-Hsuan ChenInstitute of Epidemiology and Preventive Medicine, Department of Public Health, National Taiwan University, Taipei 10055, Taiwan. ponponmiao@gmail.com.ORCID 0000-0002-1182-8191
Ming-Cheng ChangDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 10041, Taiwan. mcchang@iner.gov.tw.
Hsiu-Ping LinDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 10041, Taiwan. wfc5166@gmail.com.
Yu-Hao HuDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 10041, Taiwan. jinmaw@gmail.com.
Ying-Cheng ChiangDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 10041, Taiwan. ycchiang@ntuh.gov.tw.ORCID 0000-0002-8958-5222
Wen-Fang ChengDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 10041, Taiwan. wenfangcheng@yahoo.com.
Chi-An ChenDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei 10041, Taiwan. chianchen@ntu.edu.tw.

Funding

Ministry of Science and Technology, Taiwan 104-2314-B-002-108-MY2 and 106-2314-B-002 -194 -MY2National Taiwan University Hospital NTUH.104-S2711 and 105-M3347
6 · The paper itself

Abstract

Epithelial ovarian cancer patients usually relapse after primary management. We utilized the support vector machine algorithm to develop a model for the chemo-response using the Cancer Cell Line Encyclopedia (CCLE) and validated the model in The Cancer Genome Atlas (TCGA) and the GSE9891 dataset. Finally, we evaluated the feasibility of the model using ovarian cancer patients from our institute. The 10-gene predictive model demonstrated that the high response group had a longer recurrence-free survival (RFS) (log-rank test,

Indexed as

chemotherapymachine learningmicroarrayovarian cancerpredictive model

Identifiers

PMID30823599
PMCPMC6406249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.