Evidence map›Paper›PMID 30823414›Full record

ReviewNutrients2019

Autism Spectrum Disorders and the Gut Microbiota.

Antonella Fattorusso, Lorenza Di Genova, Giovanni Battista Dell'Isola, Elisabetta Mencaroni, Susanna Esposito

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04948814 (Clinical Trial of Fecal Microbiota Transplantation in Children With Autism Spectrum Disorder), which is not on this map. Cited by 253 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
253citing papers in PubMed, 9 pooled it
33.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04948814 phase1unknown statusnot on this mapstarted 2022, after this paper: background citation

Clinical Trial of Fecal Microbiota Transplantation in Children With Autism Spectrum Disorder

TypeinterventionalSponsorTongji HospitalRan2022 to 2024Enrolled40ConditionsAutism Spectrum DisorderArmsFecal microbiota transplantation, Vancomycin
3 · Its place in the literature

Who cites it

253 citing papers in PubMed, 9 syntheses or guidelines pooled it, 470 citations in OpenAlex.

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193 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Antonella FattorussoPediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06132 Perugia, Italy. antonella.fattorusso@libero.it.
Lorenza Di GenovaPediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06132 Perugia, Italy. lory.digenova@gmail.com.
Giovanni Battista Dell'IsolaPediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06132 Perugia, Italy. Giovanni.dellisola@gmail.com.
Elisabetta MencaroniPediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06132 Perugia, Italy. elisabetta.mencaroni@ospedale.perugia.it.
Susanna EspositoPediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06132 Perugia, Italy. susanna.esposito@unimi.it.ORCID 0000-0003-4103-2837
University of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, there has been an emerging interest in the possible role of the gut microbiota as a co-factor in the development of autism spectrum disorders (ASDs), as many studies have highlighted the bidirectional communication between the gut and brain (the so-called "gut-brain axis"). Accumulating evidence has shown a link between alterations in the composition of the gut microbiota and both gastrointestinal and neurobehavioural symptoms in children with ASD. The aim of this narrative review was to analyse the current knowledge about dysbiosis and gastrointestinal (GI) disorders in ASD and assess the current evidence for the role of probiotics and other non-pharmacological approaches in the treatment of children with ASD. Analysis of the literature showed that gut dysbiosis in ASD has been widely demonstrated; however, there is no single distinctive profile of the composition of the microbiota in people with ASD. Gut dysbiosis could contribute to the low-grade systemic inflammatory state reported in patients with GI comorbidities. The administration of probiotics (mostly a mixture of

Indexed as

DysbiosisGastrointestinal MicrobiomeAutism Spectrum DisorderHumansAutism spectrum disorderbraingut microbiotamicrobiota transfer therapyprobiotic

Identifiers

PMID30823414
PMCPMC6471505
OpenAlexW2916032641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.