Evidence map›Paper›PMID 30822560›Full record

ArticleEnvironmental research2019

Comparison of bone lead measured via portable x-ray fluorescence across and within bones.

Aaron J Specht, Aisha S Dickerson, Marc G Weisskopf

Open access · greenAbstract readComparative Study
In one paragraph

Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Ways to Measure Metals: From ICP-MS to XRF.Current environmental health reports · 2025
    Review
  5. Article
  6. A State-of-the-Science Review on Metal Biomarkers.Current environmental health reports · 2023
    Review
  7. Article
  8. Association of environmental lead toxicity and hematologic outcomes in patients with advanced kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Aaron J SpechtHarvard T.H. Chan School of Public Health, Boston, MA 02115, United States. Electronic address: aspecht@hsph.harvard.edu.
Aisha S DickersonHarvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
Marc G WeisskopfHarvard T.H. Chan School of Public Health, Boston, MA 02115, United States.
Harvard University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
Early and late-life metal exposures and Alzheimer's diseaseR01ES024165 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI WEISSKOPF, MARC G · 2014 to 2019
$3.3M
Validation of Portable XRF for In Vivo Measurement of Heavy Metal ExposuresR21ES024700 · NIEHS · RUSH UNIVERSITY MEDICAL CENTER · PI NIE, LINDA H, WEISSKOPF, MARC G · 2015 to 2018
$712k
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES024165NIEHS NIH HHS R21 ES024700NIEHS NIH HHS T32 ES007069
6 · The paper itself

Abstract

backgroundBone lead measured via x-ray fluorescence (XRF) has been used for decades in health studies. A portable XRF device for bone lead measurement is gaining in popularity for its ease of use and shorter measurement times. Previous XRF devices have measured different bone types in order to sample both cortical and trabecular bone, in which lead has different half residence times.

objectiveThe portable XRF uses lower energy to measure bone lead than previous devices, and, thus, only measures the surface of the bone. Because all bones have a cortical shell, we hypothesized that portable XRF bone lead measurements would be similar regardless of the bone measured.

methodsThis study tested differences in portable XRF bone lead measurements across different cortical and trabecular bones in measurements made on 31 cadavers. We also compared tissue thicknesses overlying different bones, which can impact portable XRF measurements.

resultsThe correlation coefficients found between bones were higher (rho ~0.4) than previous K-shell XRF bone measurements in cortical and trabecular over the same range of values (rho~0.2). The concentrations were shown to vary non-significantly across different bones within individuals.

Indexed as

Bone and BonesLeadCadaverFluorescenceHumansX-RaysLeadBiomarkersBoneChronic diseaseCumulative exposureHeavy metal toxicity

Identifiers

PMID30822560
PMCPMC6511307
OpenAlexW2917912491

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.