ArticleEnvironmental research2019
Serum perfluoroalkyl substances and lung function in adolescents exposed to the World Trade Center disaster.
Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Asthma and decreased lung function in children exposed to perfluoroalkyl and polyfluoroalkyl substances (PFAS): An updated meta-analysis unveiling research gaps.Environmental research · 2024Pooled it
- Health Impacts of the World Trade Center Disaster-A Call to Study Those Exposed at a Young Age.American journal of industrial medicine · 2026Article
- Review
- Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and incidence of asthma and wheeze in childhood: A register-based cohort study in Ronneby, Sweden.PLoS medicine · 2026Article
- Associations of PFAS and pesticides with lung function changes from adolescence to young adulthood in the ESPINA study.International journal of hygiene and environmental health · 2025Article
- Association of environmental pollutants with asthma and allergy, and the mediating role of oxidative stress and immune markers in adolescents.Environmental research · 2025Article
- Per and poly-fluoroalkyl substances and respiratory health in an Inuit community.Environmental health : a global access science source · 2024Article
- Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS).Environmental health : a global access science source · 2023Review
- Scientific Value of the Sub-Cohort of Children in the World Trade Center Health Registry.International journal of environmental research and public health · 2022Article
- Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age.Scientific reports · 2022Article
- Health effects following exposure to dust from the World Trade Center disaster: An update.Life sciences · 2022Review
- Bio-surveillance of environmental pollutants in the population of Kinshasa, Democratic Republic of Congo (DRC): a small pilot study.Archives of public health = Archives belges de sante publique · 2021Article
- Perfluoroalkyl substances and immune cell counts in adults from the Mid-Ohio Valley (USA).Environment international · 2021Article
- Review
- The Development of a WTC Environmental Health Center Pan-Cancer Database.International journal of environmental research and public health · 2021Article
- Scoping Review-The Association between Asthma and Environmental Chemicals.International journal of environmental research and public health · 2021Article
- World Trade Center Health Program: First Decade of Research.International journal of environmental research and public health · 2020Review
- High-Throughput UHPLC-MS/MS Measurement of Per- and Poly-Fluorinated Alkyl Substances in Human Serum.Journal of analytical toxicology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
The effects of childhood exposure to perfluoroalkyl substances (PFASs) on lung function remain mostly unknown. Previous research indicates that children living or going to school near the World Trade Center (WTC) disaster were exposed to high levels of PFASs, among other toxic chemicals. To explore the effects of PFAS exposure on lung function, we measured serum PFASs in a cohort of children from the WTC Health Registry and a matched control group. Perfluorooctanesulfonate had the highest median concentrations in both groups (WTCHR = 3.72 ng/mL, Comparison = 2.75 ng/mL), while the lowest median concentrations were seen for perfluoroundecanoic acid (WTCHR = 0.12 ng/mL, Comparison = 0.01 ng/mL). Lung function outcomes were measured by spirometry, plethysmography, and oscillometry. Asthma diagnosis and serum eosinophil count were also recorded. We examined the relationships of each PFAS with lung function parameters and eosinophil count using linear regressions. Odds ratios for asthma were obtained for each PFAS using logistic regression. The effect of total PFASs on these outcomes was also assessed. All regression models were adjusted for sex, race/ethnicity, age, body mass index (BMI) and tobacco smoke exposure. We found that serum PFASs were not statistically associated with the measured lung function parameters, asthma diagnosis, or eosinophil count in this cohort (p < 0.05). These findings highlight the need for more longitudinal studies to explore the long-term effects of childhood PFAS exposure on lung function past adolescence and early adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.