Evidence map›Paper›PMID 30822539›Full record

ArticleBiochimica et biophysica acta. Proteins and proteomics2019

Inhibition of ricin A-chain (RTA) catalytic activity by a viral genome-linked protein (VPg).

Valentina R Aitbakieva, Rahimah Ahmad, Shaneen Singh, Artem V Domashevskiy

Open access · greenAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Proteins and proteomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Valentina R AitbakievaDepartment of Sciences, John Jay College of Criminal Justice, the City University of New York, New York 10019, NY, United States of America.
Rahimah AhmadDepartment of Biology, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States of America.
Shaneen SinghDepartment of Biology, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States of America.
Artem V DomashevskiyDepartment of Sciences, John Jay College of Criminal Justice, the City University of New York, New York 10019, NY, United States of America. Electronic address: adomashevskiy@jjay.cuny.edu.
City University of New York · USBrooklyn College · USJohn Jay College of Criminal Justice · US

Funding

Development of a Novel Inhibitor of Ricin: A Potential Therapeutic Lead against Deadly Shiga and Related ToxinsR15AI124044 · NIAID · JOHN JAY COLLEGE OF CRIMINAL JUSTICE · PI DOMASHEVSKIY, ARTEM VICTOR · 2017 to 2017
$445k
NIAID NIH HHS R15 AI124044
6 · The paper itself

Abstract

Ricin is a plant derived protein toxin produced by the castor bean plant (Ricinus communis). The Centers for Disease Control (CDC) classifies ricin as a Category B biological agent. Currently, there is neither an effective vaccine that can be used to protect against ricin exposure nor a therapeutic to reverse the effects once exposed. Here we quantitatively characterize interactions between catalytic ricin A-chain (RTA) and a viral genome-linked protein (VPg) from turnip mosaic virus (TuMV). VPg and its N-terminal truncated variant, VPg

Indexed as

AnimalsCell-Free SystemModels, MolecularPotyvirusProtein BindingRabbitsReticulocytesRicinRicinusRNA, Ribosomal, 28SSequence DeletionThermodynamicsViral ProteinsRicinRNA, Ribosomal, 28SViral ProteinsDepurinationFluorescenceGenome-linked viral protein (VPg)Protein-protein interactionsRibosome inactivating protein (RIP)Ricin A-chain (RTA)

Identifiers

PMID30822539
PMCPMC7219317
OpenAlexW2916018731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.