Evidence map›Paper›PMID 30822511›Full record

ArticleJournal of cardiac failure2019

Exercise Ventilatory Efficiency in Older and Younger Heart Failure Patients With Preserved Ejection Fraction.

Joshua R Smith, Barry A Borlaug, Thomas P Olson

Abstract read
In one paragraph

Article in Journal of cardiac failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Ventilatory limitations in patients with HFpEF and obesity.Respiratory physiology & neurobiology · 2023
    Article
  4. Ventilatory efficiency in pulmonary vascular diseases.European respiratory review : an official journal of the European Respiratory Society · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joshua R SmithDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester Minnesota. Electronic address: smith.joshua1@mayo.edu.
Barry A BorlaugDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester Minnesota.
Thomas P OlsonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester Minnesota.

Funding

Peripheral Mechanisms of Cardiopulmonary Control during ExerciseR01HL126638 · NHLBI · MAYO CLINIC ROCHESTER · PI OLSON, THOMAS PATRICK · 2015 to 2019
$2.9M
HL-Inorganic Nitrite to Enhance Benefits from Exercise Training in Heart Failure with preserved Ejection FractionR01HL128526 · NHLBI · MAYO CLINIC ROCHESTER · PI BORLAUG, BARRY A. · 2016 to 2019
$2.4M
American Heart Association-American Stroke Association 18POST33990251NHLBI NIH HHS R01 HL126638NHLBI NIH HHS R01 HL128526
6 · The paper itself

Abstract

backgroundPatients with heart failure with preserved ejection fraction (HFpEF) exhibit pulmonary abnormalities, but the studies to date have reported wide variability in the ventilatory equivalent for carbon dioxide (V̇ METHODS AND

resultsEighteen older (O; 80 ± 4 y) and 19 younger (Y; 59 ± 7 y) HFpEF patients performed cardiopulmonary exercise testing to volitional fatigue. Measurements of arterial blood gases were used to derive V

conclusionsOlder HFpEF patients exhibit greater ventilatory inefficiency resulting from elevated physiologic dead space during peak exercise compared with younger HFpEF patients. These results suggest that aging can worsen the pathophysiologic mechanisms underlying ventilatory efficiency during exercise in HFpEF.

Indexed as

AgedAged, 80 and overAgingBlood Gas AnalysisCarbon DioxideDisease ProgressionExercise TestExercise ToleranceFemaleHeart FailureHumansHyperventilationLungMaleMiddle AgedOxygen ConsumptionCarbon DioxideagingBreathing strategyhyperventilationphysiologic dead space

Identifiers

PMID30822511
PMCPMC13077655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.