Evidence map›Paper›PMID 30822501›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2019

Differential metabolism of clinically-relevant progestogens in cell lines and tissue: Implications for biological mechanisms.

Salndave B Skosana, John G Woodland, Meghan Cartwright, Kim Enfield, Maleshigo Komane, Renate Louw-du Toit, Zephne van der Spuy, Chanel Avenant, Donita Africander, Karl-Heinz Storbeck and 1 more

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In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Salndave B SkosanaDepartment of Molecular and Cell Biology, University of Cape Town, South Africa.
John G WoodlandDepartment of Molecular and Cell Biology, University of Cape Town, South Africa.
Meghan CartwrightDepartment of Biochemistry, Stellenbosch University, South Africa.
Kim EnfieldDepartment of Molecular and Cell Biology, University of Cape Town, South Africa.
Maleshigo KomaneDepartment of Molecular and Cell Biology, University of Cape Town, South Africa.
Renate Louw-du ToitDepartment of Biochemistry, Stellenbosch University, South Africa.
Zephne van der SpuyDepartment of Obstetrics and Gynaecology, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa.
Chanel AvenantDepartment of Molecular and Cell Biology, University of Cape Town, South Africa.
Donita AfricanderDepartment of Biochemistry, Stellenbosch University, South Africa.
Karl-Heinz StorbeckDepartment of Biochemistry, Stellenbosch University, South Africa.
Janet P HapgoodDepartment of Molecular and Cell Biology, University of Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa. Electronic address: Janet.Hapgood@uct.ac.za.
University of Cape Town · ZAStellenbosch University · ZA

Funding

Combination treatment for protection against HIV1 and pregnancyR01HD083026 · NICHD · UNIVERSITY OF CAPE TOWN · PI HAPGOOD, JANET PATRICIA, HEL, ZDENEK · 2015 to 2019
$2.5M
NICHD NIH HHS R01 HD083026
6 · The paper itself

Abstract

Steroid hormones regulate a variety of physiological processes, including reproductive function, and are widely used in hormonal therapy. Synthetic progestogens, or progestins, were designed to mimic progesterone (P

Indexed as

AnimalsCell LineChlorocebus aethiopsContraceptive Agents, FemaleDesogestrelHumansLevonorgestrelMedroxyprogesterone AcetateNorethindroneNorprogesteronesProgesteroneProgestinsTandem Mass SpectrometryContraceptive Agents, FemaleDesogestreletonogestrelLevonorgestrelMedroxyprogesterone AcetateNorethindroneNorprogesteronesProgesteroneProgestinsST 1435ContraceptivesMetabolismProgesteroneProgestinsSteroidsUHPSFC-MS/MS

Identifiers

PMID30822501
PMCPMC6646820
OpenAlexW2916033498

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.