ArticleBrain, behavior, and immunity2020
Longitudinal changes of inflammatory biomarkers moderate the relationship between recent stressful life events and prospective symptoms of depression in a diverse sample of urban adolescents.
Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Inflammation and depression in young people: a systematic review and proposed inflammatory pathways.Molecular psychiatry · 2022Pooled it
- A neuroimmune framework for understanding adolescent stress and risk of alcohol misuse.Brain, behavior, & immunity - health · 2026Review
- DNA methylation of the IL6R gene moderates the association between biopsychosocial factors and depression.Translational psychiatry · 2025Article
- An Integrated Immuno-Reward Model of Adolescent Depression: Theory, Evidence, and Implications.Current directions in psychological science · 2025Article
- Higher inflammatory proteins predict future depressive symptom severity among adolescents with lower emotional clarity.Brain, behavior, and immunity · 2024Article
- The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression.Molecular psychiatry · 2024Article
- C-Reactive Protein Does Not Predict Future Depression Onset in Adolescents: Preliminary Findings from a Longitudinal Study.Journal of child and adolescent psychopharmacology · 2024Article
- Depressed, stressed, and inflamed: C-reactive protein linked with depression symptoms in midlife women with both childhood and current life stress.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Neuroimmune mechanisms connecting violence with internalizing symptoms: A high-dimensional multimodal mediation analysis.Human brain mapping · 2024Article
- Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents.Brain, behavior, & immunity - health · 2024Article
- Biomarkers of Stress and Inflammation in Children.Biological research for nursing · 2023Article
- Cytokine alterations in pediatric internalizing disorders: Systematic review and exploratory multi-variate meta-analysis.Brain, behavior, & immunity - health · 2022Article
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- Applications of psychoneuroimmunology models of toxic stress in prevention and intervention efforts across early development.Brain, behavior, & immunity - health · 2021Article
- Lack of Associations Between C-Reactive Protein and Mood and Anxiety Symptoms in Adolescents.Journal of child and adolescent psychopharmacology · 2021Article
- Concurrent and Longitudinal Associations of Sex and Race with Inflammatory Biomarkers during Adolescence.Journal of youth and adolescence · 2021Article
- Longitudinal relationships of cytokines, depression and anhedonia in depressed adolescents.Brain, behavior, and immunity · 2021Article
- Higher Levels of Pro-inflammatory Cytokines Are Associated With Higher Levels of Glutamate in the Anterior Cingulate Cortex in Depressed Adolescents.Frontiers in psychiatry · 2021Article
- Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression.Depression and anxiety · 2020Article
- Exploring Inflammation and Stress as Biological Correlates of Symptoms in Children With Advanced Cancer: A Longitudinal Feasibility Study.Journal of pediatric hematology/oncology nursingArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
This study investigated whether longitudinal changes in inflammatory physiology moderated the relationship between recent stressful life events and subsequent depressive symptoms in adolescence. A diverse sample of adolescents representative of an urban community (N = 129; Age at baseline = 12.5 years; 48.8% female; 55.0% African American) completed measures of stressful life events, depressive symptoms, and two annual blood draws (BD1 and BD2). Controlling for inflammatory activity at BD1, depression at BD1, demographics and the time between assessments, increases in interleukin-6 (IL-6; b = 0.878, p = .007) and C-reactive protein (CRP; b = 0.252, p = .024) from BD1 to BD2 interacted with recent stressful life events before BD1 to predict severity of depressive symptoms at BD2. Similar associations were evident for IL-6 (b = 2.074, p = .040) and CRP (b = 0.919, p = .050) when considering acute stressful life events that had occurred within the two weeks before the first blood collection. More frequent stressful life events before BD1 predicted significantly more severe depressive symptoms at BD2, but only for adolescents with moderate (50th percentile) and high (84th percentile) levels of IL-6 and CRP at BD2. In conclusion, adolescents who experienced both recent stressful life events and larger increases in inflammatory activity following these stressors were at increased risk for more severe depressive symptoms after approximately one year. The findings indicate that the interaction of stress and larger changes in inflammatory activity following these stressors are prognostic risk factors for depression severity in adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.