Evidence map›Paper›PMID 30822440›Full record

ArticleNeurochemistry international2019

Metabolomic analyses of vigabatrin (VGB)-treated mice: GABA-transaminase inhibition significantly alters amino acid profiles in murine neural and non-neural tissues.

Dana C Walters, Erland Arning, Teodoro Bottiglieri, Erwin E W Jansen, Gajja S Salomons, Madalyn N Brown, Michelle A Schmidt, Garrett R Ainslie, Jean-Baptiste Roullet, K Michael Gibson

Open access · greenAbstract read
In one paragraph

Article in Neurochemistry international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Dana C WaltersDepartment of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
Erland ArningBaylor Scott & White Research Institute, Institute of Metabolic Disease, Dallas, TX, USA.
Teodoro BottiglieriBaylor Scott & White Research Institute, Institute of Metabolic Disease, Dallas, TX, USA.
Erwin E W JansenMetabolic Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Center, the Netherlands.
Gajja S SalomonsMetabolic Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Center, the Netherlands.
Madalyn N BrownDepartment of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
Michelle A SchmidtDepartment of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
Garrett R AinslieDepartment of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
Jean-Baptiste RoulletDepartment of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
K Michael GibsonDepartment of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA. Electronic address: mike.gibson@wsu.edu.
Washington State University Spokane · USAmsterdam University Medical Centers · NLBaylor Medical Center at Garland · US

Funding

Rapalog Therapy in Heritable and Vigabatrin-Induced GABA Metabolic DisordersR01EY027476 · NEI · WASHINGTON STATE UNIVERSITY · PI GIBSON, K MICHAEL · 2017 to 2020
$1.7M
NEI NIH HHS R01 EY027476
6 · The paper itself

Abstract

The anticonvulsant vigabatrin (VGB; Sabril

Indexed as

4-Aminobutyrate TransaminaseAmino AcidsAnimalsAnticonvulsantsBrainDose-Response Relationship, DrugLiverMaleMetabolomeMetabolomicsMiceMice, Inbred C57BLRetinaVigabatrin4-Aminobutyrate TransaminaseAmino AcidsAnticonvulsantsVigabatrin2-Aminoadipic acidAmino acidEyeGABAGABA-TransaminasePrefrontal cortexVigabatrinVisual cortex

Identifiers

PMID30822440
PMCPMC6414070
OpenAlexW2917785222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.