ArticlePloS one2019
A multidisciplinary study of pain in cats undergoing dental extractions: A prospective, blinded, clinical trial.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
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- Demography, common disorders, cause-specific mortality and life expectancy of Ragdoll cats under primary veterinary care during 2019 in the UK.Companion animal health and genetics · 2025Article
- Feline chronic pain management: the importance of a team approach for optimal outcomes.Journal of feline medicine and surgery · 2025Review
- Effect of Simple Oral Dental Extraction on Systemic Serum Amyloid A Concentrations in Horses.Veterinary medicine and science · 2024Article
- Video-based compilation of acute pain behaviours in cats.Journal of feline medicine and surgery · 2024Article
- Neuropathic pain in cats: Mechanisms and multimodal management.Journal of feline medicine and surgery · 2024Review
- 2024 ISFM and AAFP consensus guidelines on the long-term use of NSAIDs in cats.Journal of feline medicine and surgery · 2024Article
- Periodontal disease in cats under primary veterinary care in the UK: frequency and risk factors.Journal of feline medicine and surgery · 2023Article
- Randomised, prospective, blinded, clinical trial of opioid-free injectable anaesthesia with or without multimodal analgesia in kittens undergoing ovariohysterectomy.Journal of feline medicine and surgery · 2023Article
- 2022 ISFM Consensus Guidelines on the Management of Acute Pain in Cats.Journal of feline medicine and surgery · 2022Article
- Agreement and reliability of the Feline Grimace Scale among cat owners, veterinarians, veterinary students and nurses.Scientific reports · 2021Article
- Pain behaviors before and after treatment of oral disease in cats using video assessment: a prospective, blinded, randomized clinical trial.BMC veterinary research · 2020Article
- Inter-Rater Reliability of the Feline Grimace Scale in Cats Undergoing Dental Extractions.Frontiers in veterinary science · 2020Article
- Article
- Chronic pain in cats: Recent advances in clinical assessment.Journal of feline medicine and surgery · 2019Article
- Development, Preliminary Validation, and Refinement of the Composite Oral and Maxillofacial Pain Scale-Canine/Feline (COPS-C/F).Frontiers in veterinary science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate pain scores, analgesic requirements, food intake and serum inflammatory cytokines in cats before and after clinically recommended dental treatment. Twenty-four cats were included in a prospective, blinded clinical trial. Cats were equally divided into minimal (minimal dental treatment) or severe (multiple dental extractions) oral disease groups. They were admitted (day 0) and underwent oral examination/radiographs/treatment under general anesthesia (day 1; acepromazine-hydromorphone-propofol-isoflurane-meloxicam-local anesthetic blocks). Serum inflammatory cytokines were measured on days 0 and 6. Pain was scored using the Glasgow composite measure pain scale-feline (CMPS-F). Rescue analgesia was administered with hydromorphone if CMPS-F ≥ 5/20. Dry and soft food intake (%) during 3 minutes and 2 hours, and daily soft food were calculated. The Cochran-Mantel-Haenszel and Chi-square tests, Spearman's rank correlation and linear mixed models were used for statistical analysis (alpha = 0.05). Pain scores were significantly increased in cats with severe disease when compared with baseline (up to day 4) and minimal disease (all postoperative time points). Prevalence of rescue analgesia was significantly higher in severe (91.7%) than minimal disease (0%); analgesics were required up to day 3. Pain scores and frequency of rescue analgesia were significantly correlated with the number of tooth extractions, gingival and calculus index. Prevalence of rescue analgesia was significantly correlated with the number of missing teeth, teeth extractions and gingival index. Dry and soft food intake during 3 minutes, and dry food intake during 2 hours were significantly lower in the severe than minimal disease group throughout the study. Some cytokines differed between groups between day 0 and day 6 and were associated with the presence of tooth resorption and number of missing tooth and tooth fractures. Long-term analgesia is required after dental extractions in cats with severe oral disease. This condition reduces food intake and influences serum inflammatory cytokines.
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