Evidence map›Paper›PMID 30822166›Full record

ArticleDrug delivery2019

A thermosensitive gel based on w1/o/w2 multiple microemulsions for the vaginal delivery of small nucleic acid.

Jiu Wang, Yajing Wang, Ziqiang Wang, Fan Wang, Jie He, Xiaoyun Yang, Weidong Xie, Ying Liu, Yaou Zhang

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Nanomedicine for Maternal and Fetal Health.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  3. Article
  4. Review
  5. Review
  6. [12]aneNDrug delivery · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jiu Wanga School of Pharmaceutical Sciences , Hubei University of Medicine , Shiyan , Hubei , China.
Yajing Wangc Department of Pharmacy, School of Pharmaceutical Engineering and Life Science , Changzhou University , Changzhou , Jiangsu , China.
Ziqiang Wangb Division of Life Science, Key Lab in Healthy Science and Technology , Graduate School at Shenzhen, Tsinghua University , Shenzhen , China.
Fan Wangb Division of Life Science, Key Lab in Healthy Science and Technology , Graduate School at Shenzhen, Tsinghua University , Shenzhen , China.
Jie Heb Division of Life Science, Key Lab in Healthy Science and Technology , Graduate School at Shenzhen, Tsinghua University , Shenzhen , China.
Xiaoyun Yangb Division of Life Science, Key Lab in Healthy Science and Technology , Graduate School at Shenzhen, Tsinghua University , Shenzhen , China.
Weidong Xieb Division of Life Science, Key Lab in Healthy Science and Technology , Graduate School at Shenzhen, Tsinghua University , Shenzhen , China.
Ying Liub Division of Life Science, Key Lab in Healthy Science and Technology , Graduate School at Shenzhen, Tsinghua University , Shenzhen , China.
Yaou Zhangb Division of Life Science, Key Lab in Healthy Science and Technology , Graduate School at Shenzhen, Tsinghua University , Shenzhen , China.
University Town of Shenzhen · CNTsinghua University · CNChangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aims at designing a thermosensitive gel prepared from w1/o/w2 multiple microemulsions (MMEs) for the vaginal delivery of siRNA. The w1/o/w2 MMEs were prepared by two-step emulsifications: the first step was to prepare primary emulsions (w1/o) by low energy emulsification (LEE); the second step was to obtain stable w1/o/w2 MMEs by self-emulsifying. An extensive formulation optimization process was undertaken. The final w1/o/w2 MMEs could be formed in ddH

Indexed as

Administration, IntravaginalMicrospheresAnimalsDrug Delivery SystemsEmulsionsFemaleGelsHeLa CellsHumansMiceNucleic AcidsRandom AllocationSurface-Active AgentsWaterEmulsionsGelsNucleic AcidsSurface-Active AgentsWaterlow energy emulsification (LEE)multiple microemulsions (MMEs)Small interfering RNA (siRNA)thermosensitive gelvaginal delivery

Identifiers

PMID30822166
PMCPMC6407577
OpenAlexW2920788925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.