ArticleAmerican journal of physiology. Heart and circulatory physiology2019
Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study.
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In one paragraph
Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Protective Arm of Renin-Angiotensin System: Evidence of Nephroprotective Effects Against Acute Kidney Injury.Acta physiologica (Oxford, England) · 2026Review
- Transient Middle Cerebral Artery Occlusion in Rats as a Nonclinical Model of Ischemic Stroke: A Systematic Review.Current issues in molecular biology · 2026Review
- Serum Neurofilament Light Chain Predicts Stroke Outcome and is a Potential Marker for Treatment Effects of Neural Stem Cell-derived Extracellular Vesicles in a Rat Stroke Model.Translational stroke research · 2026Article
- Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive Rats.Translational stroke research · 2025Article
- Angiotensin Type 2 Receptor Pharmacological Agonist Relieves Neurocognitive Deficits via Reducing Neuroinflammation and Microglial Engulfment of Dendritic Spines.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023Article
- Cerebral microvascular matrix metalloproteinase-3 (MMP3) contributes to vascular injury after stroke in female diabetic rats.Neurochemistry international · 2023Article
- The Angiotensin ATPharmacological reviews · 2022Review
- Contralesional angiotensin type 2 receptor activation contributes to recovery in experimental stroke.Neurochemistry international · 2022Article
- Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury.Experimental neurology · 2022Article
- Stimulation of angiotensin II receptor 2 preserves cognitive function and is associated with an enhanced cerebral vascular density after stroke.Vascular pharmacology · 2021Article
- Delayed Administration of Angiotensin Receptor (AT2R) Agonist C21 Improves Survival and Preserves Sensorimotor Outcomes in Female Diabetic Rats Post-Stroke through Modulation of Microglial Activation.International journal of molecular sciences · 2021Article
- The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: Insight from preclinical stroke studies and therapeutic potential.Cellular signalling · 2020Review
- Stroke promotes the development of brain atrophy and delayed cell death in hypertensive rats.Scientific reports · 2020Article
- Impact of the Renin-Angiotensin System on the Endothelium in Vascular Dementia: Unresolved Issues and Future Perspectives.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Wael EldahshanProgram in Clinical and Experimental Therapeutics, Charlie Norwood Veterans Affairs Medical Center and University of Georgia, College of Pharmacy , Augusta, Georgia.
Tauheed IshratProgram in Clinical and Experimental Therapeutics, Charlie Norwood Veterans Affairs Medical Center and University of Georgia, College of Pharmacy , Augusta, Georgia.
Bindu PillaiProgram in Clinical and Experimental Therapeutics, Charlie Norwood Veterans Affairs Medical Center and University of Georgia, College of Pharmacy , Augusta, Georgia.
Mohammed A SayedProgram in Clinical and Experimental Therapeutics, Charlie Norwood Veterans Affairs Medical Center and University of Georgia, College of Pharmacy , Augusta, Georgia.
Abdulrahman AlwhaibiProgram in Clinical and Experimental Therapeutics, Charlie Norwood Veterans Affairs Medical Center and University of Georgia, College of Pharmacy , Augusta, Georgia.
Abdelrahman Y FoudaProgram in Clinical and Experimental Therapeutics, Charlie Norwood Veterans Affairs Medical Center and University of Georgia, College of Pharmacy , Augusta, Georgia.
Adviye ErgulDepartment of Physiology, Augusta University , Augusta, Georgia.
Susan C FaganProgram in Clinical and Experimental Therapeutics, Charlie Norwood Veterans Affairs Medical Center and University of Georgia, College of Pharmacy , Augusta, Georgia.
University of Georgia · USCharlie Norwood VA Medical Center · USAugusta University · US
Funding
Vascular Injury and Recovery in Diabetic Ischemic StrokeRF1NS083559 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ERGUL, ADVIYE · 2020 to 2022
$2.4MProgressive Post Stroke Cognitive Impairment:Mechanisms & InterventionR01NS104573 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ERGUL, ADVIYE, SHENOY, SOMANATH P RAMMOHAN · 2018 to 2022
$2.3MVascular Injury and Recovery in Diabetic Ischemic StrokeR01NS083559 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ERGUL, ADVIYE · 2014 to 2018
$1.9MMechanisms of Vascular Protection after Acute StrokeR01NS063965 · NINDS · UNIVERSITY OF GEORGIA · PI FAGAN, SUSAN C · 2009 to 2013
$1.4MAngiotensin receptor agonism to promote recovery after strokeR21NS088016 · NINDS · UNIVERSITY OF GEORGIA · PI FAGAN, SUSAN C · 2014 to 2015
$645kCerebral Arteriole Structure/Function in Diabetic Ischemic Brain InjuryI01BX000347 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI ERGUL, ADVIYE · 2009 to 2025
–BLRD VA I01 BX000347BLRD VA I01 BX000891NINDS NIH HHS R01 NS063965NINDS NIH HHS R01 NS083559NINDS NIH HHS R01 NS104573NINDS NIH HHS R21 NS088016NINDS NIH HHS RF1 NS083559
Abstract
The angiotensin II type 2 receptor (AT
Indexed as
AnimalsBehavior, AnimalBrainCells, CulturedDisease Models, AnimalEndothelial CellsFemaleInfarction, Middle Cerebral ArteryMaleMicrovesselsMotor ActivityNeuroprotective AgentsPilot ProjectsPPAR gammaRats, WistarReceptor, Angiotensin, Type 2Agtr2 protein, ratN-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-isobutylthiophene-2-sulfonamideNeuroprotective AgentsPPAR gammaReceptor, Angiotensin, Type 2SulfonamidesThiophenesATRbrain microvascular endothelial cellscompound 21female rodentsischemic strokeperoxisome proliferator-activated receptor-γ
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.