ArticleAmerican journal of physiology. Heart and circulatory physiology2019
Muscle metaboreflex-induced central blood volume mobilization in heart failure.
Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Exercise, Prostaglandin ECells · 2026Review
- Mechanisms mediating muscle metaboreflex control of cardiac output during exercise: Impaired regulation in heart failure.Experimental physiology · 2025Review
- Cardiac output-mediated regulation of cerebral blood flow during exercise: Clinical perspectives on the indirect impact of muscle metaboreflex.Experimental physiology · 2025Review
- Muscle metaboreflex stimulates the cardiac sympathetic afferent reflex causing positive feedback amplification of sympathetic activity: effect of heart failure.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Pulmonary blood volume assessment from a standard cardiac rubidium-82 imaging protocol: impact of adenosine-induced hyperemia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Augmented sympathoexcitation slows postexercise heart rate recovery.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Blood flow restriction training activates the muscle metaboreflex during low-intensity sustained exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Muscle metaboreflex adaptations to exercise training in health and disease.European journal of applied physiology · 2021Review
- Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Ventricular contraction and relaxation rates during muscle metaboreflex activation in heart failure: are they coupled?Experimental physiology · 2021Article
- Exercise intolerance and fatigue in chronic heart failure: is there a role for group III/IV afferent feedback?European journal of preventive cardiology · 2020Article
- Muscle metaboreflex-induced increases in effective arterial elastance: effect of heart failure.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Underperfusion of active skeletal muscle causes metabolites to accumulate and stimulate group III and IV skeletal muscle afferents, which triggers a powerful pressor response termed the muscle metaboreflex. Muscle metaboreflex activation (MMA) during submaximal dynamic exercise in healthy individuals increases arterial pressure mainly via substantial increases in cardiac output (CO). The increases in CO occur via the combination of tachycardia and increased ventricular contractility. Importantly, MMA also elicits substantial central blood volume mobilization, which allows the ventricular responses to sustain the increases in CO. Otherwise preload would fall and the increases in CO could not be maintained. In subjects with systolic heart failure (HF), the ability to increase CO during exercise and MMA is markedly reduced, which has been attributed to impaired ventricular contractility. Whether the ability to maintain preload during MMA in HF is preserved is unknown. Using a conscious chronically instrumented canine model, we observed that MMA in HF is able to raise central blood volume similarly as in normal subjects. Therefore, the loss of the ability to raise CO during MMA in HF is not because of the loss of the ability to mobilize blood volume centrally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.