ArticleHemodialysis international. International Symposium on Home Hemodialysis2019
Depressive symptoms, frailty, and mortality among dialysis patients.
Article in Hemodialysis international. International Symposium on Home Hemodialysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Frailty risk prediction models in maintenance hemodialysis patients: a systematic review and meta-analysis of studies from China.Renal failure · 2025Pooled it
- Association Between Frailty and Mortality, Falls and Hospitalisation Among Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis.Nursing open · 2025Pooled it
- Association between frailty and adverse outcomes in patients undergoing maintenance hemodialysis: a systematic review and meta-analysis.Renal failure · 2024Pooled it
- Recommendations for the management of frailty in chronic kidney disease: a consensus report.Nature reviews. Nephrology · 2026Review
- Bibliometric analysis of frailty in dialysis patients: knowledge mapping and trends.International urology and nephrology · 2026Review
- Frailty, All-Cause Mortality, and Hospitalization in Patients on Maintenance Hemodialysis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Review
- Association between B-cell activating factor and future depressive symptoms in hemodialysis patients.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Observational
- The mediating role of psychological resilience in the relationship between frailty and self-efficacy among dialysis patients.Frontiers in psychiatry · 2025Article
- Understanding perceived stigma and depression symptoms in maintenance hemodialysis patients: a network perspective.Frontiers in psychology · 2025Article
- Article
- Prevalence and risk factors of pre-frailty and frailty in hemodialysis patients in central China.Scientific reports · 2024Article
- Use of frailty assessment instruments in nephrology populations: a scoping review.BMC geriatrics · 2023Article
- Dialysis Patient Experiences During the COVID-19 Pandemic: A Survey Study.Kidney medicine · 2023Article
- Depression is associated with frailty and lower quality of life in haemodialysis recipients, but not with mortality or hospitalization.Clinical kidney journal · 2023Article
- Somatic Symptoms of Depression Lose Association with Mortality upon Adjustment for Frailty: Analysis from the Fitness Haemodialysis Cohort.International journal of nephrology · 2023Article
- Depressive Symptoms at Kidney Transplant Evaluation and Access to the Kidney Transplant Waitlist.Kidney international reports · 2022Article
- Correlations, agreement and utility of frailty instruments in prevalent haemodialysis patients: baseline cohort data from the FITNESS study.Clinical kidney journal · 2022Article
- The depressed frail phenotype as a risk factor for mortality in older adults: A prospective cohort in Peru.Heliyon · 2022Article
- Study on the Clinical Implications of NLR and PLR for Diagnosing Frailty in Maintenance Hemodialysis Patients and Their Correlations with Patient Prognosis.Journal of healthcare engineering · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
introductionFrailty and depression are highly prevalent in the dialysis population, but the association between them, the risk factors for their development, and their independent associations with mortality have not been studied.
methodsWe examined 771 patients enrolled in the ACTIVE/ADIPOSE prevalent dialysis cohort study. Fried's frailty phenotype and the Center for Epidemiologic Studies Depression score were used to determine frailty and presence of depressive symptoms, respectively. We assessed the baseline association between frailty and depressive symptoms, whether one entity is a risk factor for development of the other, and associations between frailty and depressive symptoms with mortality.
findingsAt baseline, 13.1% of our population screened positive for depressive symptoms, 21.8% met criteria for frailty, and 10.0% met criteria for both. During follow-up, 26.6% of our population developed frailty and 12.7% developed depressive symptoms. Using multivariable logistic regression, baseline depressive symptoms were associated with 2.14-fold higher odds of being frail at baseline (95% confidence interval [CI] 1.45-3.17) and with a 2.16-fold higher odds of incident frailty during follow-up (95% CI 1.22-3.82). However, baseline frailty was not associated with incident depressive symptoms. Frailty and depressive symptoms were independent predictors of mortality in time-varying survival analysis (meeting frailty criteria: hazard ratio [HR] 1.53, 95% CI 1.05-2.23; depressive symptoms: HR 2.21, 95% CI 1.50-3.25). DISCUSSION: Frailty and depressive symptoms remained highly prevalent over time and were strongly associated with one another and independently associated with mortality among dialysis patients. Future studies should investigate whether interventions for depression could potentially mitigate the appearance of frailty and its associated poor outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.