ArticleAnatolian journal of cardiology2019
D-Dimer is a strong predictor of in-hospital mortality in patients with infective endocarditis.
Article in Anatolian journal of cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 9 citations in OpenAlex.
- Predictive strength of inflammatory scores for in-hospital mortality in infective endocarditis.Herz · 2025Article
- Evaluation of parameters predicting in-hospital mortality and septic embolisms in patients with infective endocarditis.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024Article
- Comparison of Biochemical Markers and Echocardiographic Parameters in the Diagnosis of Prosthetic Valve and Intracardiac Device Endocarditis.Anatolian journal of cardiology · 2022Article
- Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis.Journal of clinical medicine · 2021Article
- Prognostic value of D-dimer for adverse outcomes in patients with infective endocarditis: an observational study.BMC cardiovascular disorders · 2021Observational
- High level of D-dimer predicts ischemic stroke in patients with infective endocarditis.Journal of clinical laboratory analysis · 2020Article
- Predictive Value of D-Dimer for In-Hospital Mortality in Non-Diabetic Patients with Non-ST-segment Elevation Myocardial Infarction.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveInfective endocarditis (IE) is a rare disease with a high mortality. Therefore, prognostic markers can play an important role in the follow-up. In this study, we investigated the relationship between the D-dimer (DD) level and in-hospital mortality and complications in patients with IE, because DD indicates both the fibrin turnover in vegetation and the autoimmune inflammatory response in patients with IE.
methodsSeventy-nine patients with IE were included in the study. In-hospital death for any reason was considered to be the primary endpoint. Secondary endpoints were embolism and in-hospital death or embolism.
resultsIn-hospital mortality occurred in 31 (39%) patients. The DD level was significantly higher in the group with in-hospital mortality [median (interquartile range) values 3048.0 (4911.0) vs. 556.0 (1100.2) ng/mL, p<0.001]. When the DD level was 795 ng/mL or higher, the sensitivity was 83.5%, specificity was 66.7%, the positive predictive value was 66.4%, and the negative predictive value was 94.1%, to determine in-hospital mortality. Categorically, the DD level of 795 ng/mL or higher was found to increase the risk of in-hospital mortality by 29 times (odds ratio=29; 95% confidence interval=6.13-137.11; p<0.001). In a multiple logistic regression analysis, the DD level was found to be the best independent predictor of in-hospital mortality (the AUC value only for DD was 0.86, and for the multiple logistic regression model, it was 0.89, p=0.48). A significant correlation was found between the DD level and in-hospital death or embolization [1863.0 (4914, 0) vs. 376 (607, 0) ng/mL, p<0.001]. In the multiple logistic regression analysis, DD was found to be the best independent parameter showing in-hospital mortality or embolization (the AUC value was 0.83 for DD, and 0.84 for the multiple logistic regression analysis, p=0.69).
conclusionThese findings support that a high DD is a strong parameter predicting in-hospital mortality, and in-hospital mortality or embolic events in patients with IE.
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