Evidence map›Paper›PMID 30821592›Full record

ArticleAutophagy2019

Autophagy-mediated

Minggang Peng, Jingjing Wang, Zhongxian Tian, Dongyun Zhang, Honglei Jin, Claire Liu, Jiawei Xu, Jingxia Li, Xiaohui Hua, Jiheng Xu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Emerging Roles of Autophagy-Related MicroRNAs in Cancer.International journal of biological sciences · 2021
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Minggang Penga Department of Environmental Medicine and Urology, New York University School of Medicine , Tuxedo , NY , USA.
Jingjing Wangb School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou , Zhejiang , China.
Zhongxian Tianb School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou , Zhejiang , China.
Dongyun Zhanga Department of Environmental Medicine and Urology, New York University School of Medicine , Tuxedo , NY , USA.
Honglei Jinb School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou , Zhejiang , China.
Claire Liua Department of Environmental Medicine and Urology, New York University School of Medicine , Tuxedo , NY , USA.
Jiawei Xua Department of Environmental Medicine and Urology, New York University School of Medicine , Tuxedo , NY , USA.
Jingxia Lia Department of Environmental Medicine and Urology, New York University School of Medicine , Tuxedo , NY , USA.
Xiaohui Huaa Department of Environmental Medicine and Urology, New York University School of Medicine , Tuxedo , NY , USA.
Jiheng Xua Department of Environmental Medicine and Urology, New York University School of Medicine , Tuxedo , NY , USA.
Chao Huanga Department of Environmental Medicine and Urology, New York University School of Medicine , Tuxedo , NY , USA.
Chuanshu Huanga Department of Environmental Medicine and Urology, New York University School of Medicine , Tuxedo , NY , USA.
New York University · USWenzhou Medical University · CN

Funding

RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1M
Reagent/Service CoreP01CA165980 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TANG, ERIC MOON-SHONG M. · 2013 to 2023
$13.5M
MEG3 deletion drives lung tumorigenesis due to environmental nickel exposureR01CA229234 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 2019 to 2024
$2.4M
SESN2 and therapeutic effect of Isohapontigenin (ISO)R01CA217923 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX, SUN, HONG · 2018 to 2022
$2.1M
Mechanisms underlying therapeutic effect of a new compound Isorhapontigenin (ISO)R01CA177665 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HUANG, CHUANSHU · 2013 to 2018
$1.7M
NCI NIH HHS P01 CA165980NCI NIH HHS R01 CA177665NCI NIH HHS R01 CA217923NCI NIH HHS R01 CA229234NIEHS NIH HHS P30 ES000260
6 · The paper itself

Abstract

PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) is a newly identified family of Ser/Thr phosphatases that catalyzes the dephosphorylation of a conserved regulatory motif of the AGC kinases resulting in a tumor suppressive function, while CDKN1B/p27 also acts as a tumor suppressor by regulating cell cycle, senescence, apoptosis, and cell motility. Our most recent studies reveal that CDKN1B is required for PHLPP1 abundance, which contributes to the inhibition of carcinogenic arsenite-induced cell malignant transformation through inhibition of RPS6-mediated

Indexed as

RNA Stability3T3 Cells5' Untranslated RegionsAnimalsAutophagyCell MovementCells, CulturedCyclin-Dependent Kinase Inhibitor p27Down-RegulationHSP90 Heat-Shock ProteinsMiceMicroRNAsPhosphoprotein PhosphatasesProtein BiosynthesisSequestosome-1 ProteinSignal Transduction5' Untranslated RegionsCdkn1b protein, mouseCyclin-Dependent Kinase Inhibitor p27HSP90 Heat-Shock ProteinsMicroRNAsMIRN6981 microRNA, mousePHLPP1 protein, mousePhosphoprotein PhosphatasesSequestosome-1 ProteinSp1 Transcription FactorSqstm1 protein, mouseAutophagy

Identifiers

PMID30821592
PMCPMC6693457
OpenAlexW2919260242

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.