ArticleCancer medicine2019
Comprehensive analysis of age-related somatic mutation profiles in Chinese young lung adenocarcinoma patients.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Lung cancer in young individuals; risk factors and epidemiology.Journal of thoracic disease · 2025Review
- Association between genetic mutations in lung adenocarcinoma and adult body mass index: a retrospective cohort study.Frontiers in oncology · 2025Article
- A profile of lung cancer in the young population with a highlight on the Indian perspective.Frontiers in oncology · 2025Review
- The modification role and tumor association with a methyltransferase: KMT2C.Frontiers in immunology · 2024Review
- Comparison of gene mutation profile in different lung adenocarcinoma subtypes by targeted next-generation sequencing.Medical oncology (Northwood, London, England) · 2023Article
- Age-dependent genomic characteristics and their impact on immunotherapy in lung adenocarcinoma.Journal of cancer research and clinical oncology · 2023Article
- Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.BMC medical genomics · 2022Article
- Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma.BMC genomics · 2022Article
- Bioinformatics analysis reveals three key genes and four survival genes associated with youth-onset NSCLC.Open medicine (Warsaw, Poland) · 2022Article
- Immune Checkpoint Blockade in Chinese Patients With Hepatocellular Carcinoma: Characteristics and Particularity.Frontiers in oncology · 2022Review
- Next-generation Sequencing Reveals Age-dependent Genetic Underpinnings in Lung adenocarcinoma.Journal of Cancer · 2022Article
- Targeted next-generation sequencing for cancer-associated gene mutation and copy number detection in 206 patients with non-small-cell lung cancer.Bioengineered · 2021Article
- Integration of comprehensive genomic profiling, tumor mutational burden, and PD-L1 expression to identify novel biomarkers of immunotherapy in non-small cell lung cancer.Cancer medicine · 2021Article
- Somatic Mutation Profiles Revealed by Next Generation Sequencing (NGS) in 39 Chinese Hepatocellular Carcinoma Patients.Frontiers in molecular biosciences · 2021Article
- [Current Situation of Clinical Feature and Gene Phenotype of Young Adult Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020Review
- Development and validation of a 4-gene combination for the prognostication in lung adenocarcinoma patients.Journal of Cancer · 2020Article
- Comprehensive analysis of age-related somatic mutation profiles in Chinese young lung adenocarcinoma patients.Cancer medicine · 2019Article
- Pathogenic and Therapeutic Role of H3K4 Family of Methylases and Demethylases in Cancers.Indian journal of clinical biochemistry : IJCB · 2019Review
- Value of serum tumor markers in early differential diagnosis of spinal tumors and spinal infections.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung adenocarcinoma in young adults is a rare entity with the oncogenic genetic alterations associated being poorly understood. In the present study, the effect of genetic alterations in lung adenocarcinoma patients diagnosed in young patients is reported.
methodsTwenty young lung adenocarcinoma patients (age years: median: 33.5, range: 24-36) were enrolled in the current study and 24 patients who were at common age of the disease onset (age years: median: 61.5, range: 52-79) were selected for comparison. Paraffin sections of lung adenocarcinoma were analyzed using the whole-exome sequencing platform.
resultsSimilar number of somatic mutations per tumor were found in the young patients and their older counterparts. Although no age-related differences were detected in the numbers of lung adenocarcinoma patients harboring well-known gene variants, mutations in FRG1 and KMT2C were associated with a younger age especially after correcting for tobacco smoking and sex (FRG1: P = 0.027, KMT2C: P = 0.046). Five genetic variants showed higher alteration frequencies in young patients compared to the unclassified East Asian population, suggesting these mutations as disease-related hereditary germline variants.
conclusionsThese results suggest different characteristics of lung adenocarcinoma between the young and the patients at common age of onset. Young patients with lung adenocarcinoma have a distinctly unique prevalence of oncogenic genetic alterations.
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