ArticlePsychiatry and clinical neurosciences2019
Genome-wide DNA methylation investigation of glucocorticoid exposure within buccal samples.
Article in Psychiatry and clinical neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
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- Impact of acute stress exposure on genome-wide DNA methylation.Scientific reports · 2025Article
- Epigenetic signals associated with delirium replicated across four independent cohorts.Translational psychiatry · 2024Article
- Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids.Pediatric research · 2024Article
- A multi-omics data analysis workflow packaged as a FAIR Digital Object.GigaScience · 2024Article
- Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy.Epilepsy & behavior reports · 2024Article
- Epigenetic differences in stress response gene FKBP5 among children with abusive vs accidental injuries.Pediatric research · 2023Article
- Integrative Multi-omics Analysis of Childhood Aggressive Behavior.Behavior genetics · 2023Article
- The genome-wide DNA methylation profiles among neurosurgery patients with and without post-operative delirium.Psychiatry and clinical neurosciences · 2023Article
- An explorative epigenome-wide association study of plasma renin and aldosterone concentration in a Ghanaian population: the RODAM study.Clinical epigenetics · 2022Article
- DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium.Translational psychiatry · 2021Article
- Dynamic DNA Methylation Changes in theBiomolecules · 2021Article
- Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression.International journal of molecular sciences · 2021Article
- Epigenetic alterations associated with dexamethasone sodium phosphate through DNMT and TET in RPE cells.Molecular vision · 2021Article
- Bound Together: How Psychoanalysis Diminishes Inter-generational DNA Trauma.American journal of psychoanalysis · 2020Article
- Differential DNA methylation in high-grade serous ovarian cancer (HGSOC) is associated with tumor behavior.Scientific reports · 2019Article
- Neural correlates of attentional control in social anxiety disorder: the impact of early-life adversity and DNA methylation.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
22 authors at 2 institutions in 1 country.
Funding
Abstract
aimGlucocorticoids play a major role in regulating the stress response, and an imbalance of glucocorticoids has been implicated in stress-related disorders. Within mouse models, CpGs across the genome have been shown to be differentially methylated in response to glucocorticoid treatment, and using the Infinium 27K array, it was shown that humans given synthetic glucocorticoids had DNA methylation (DNAm) changes in blood. However, further investigation of the extent to which glucocorticoids affect DNAm across a larger proportion of the genome is needed.
methodsBuccal samples were collected before and after synthetic glucocorticoid treatment in the context of a dental procedure. This included 30 tooth extraction surgery patients who received 10 mg of dexamethasone. Genome-wide DNAm was assessed with the Infinium HumanMethylationEPIC array.
resultsFive CpGs showed genome-wide significant DNAm changes that were >10%. These differentially methylated CpGs were in or nearest the following genes: ZNF438, KLHDC10, miR-544 or CRABP1, DPH5, and WDFY2. Using previously published datasets of human blood gene expression changes following dexamethasone exposure, a significant proportion of genes with false-discovery-rate-adjusted significant CpGs were also differentially expressed. A pathway analysis of the genes with false-discovery-rate-adjusted significant CpGs revealed significant enrichment of olfactory transduction, pentose and glucuronate interconversions, ascorbate and aldarate metabolism, and steroid hormone biosynthesis pathways.
conclusionHigh-dose synthetic glucocorticoid administration in the setting of a dental procedure was significantly associated with DNAm changes within buccal samples. These findings are consistent with prior findings of an influence of glucocorticoids on DNAm in humans.
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