Evidence map›Paper›PMID 30821034›Full record

ArticleChembiochem : a European journal of chemical biology2019

A DFT-Assisted Topological Analysis of Four Polymorphic, S-Shaped Aβ42 Fibril Structures.

Alejandro R Foley, Jevgenij A Raskatov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alejandro R FoleyDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Physical Science Building 356, 1156 High Street, Santa Cruz, CA, 95064, USA.
Jevgenij A RaskatovDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Physical Science Building 356, 1156 High Street, Santa Cruz, CA, 95064, USA.ORCID 0000-0002-0082-9113
University of California, Santa Cruz · US

Funding

Using Chirality to Understand and Control Amyloid Beta Neuronal Uptake and ToxicityR01AG074954 · NIA · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Jevgenij Raskatov · 2022 to 2026
$1.9M
Chiral Inactivation of Amyloid beta Actions in Cytotoxicity, Synaptic transmission and PlasticityR21AG058074 · NIA · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI RASKATOV, JEVGENIJ · 2017 to 2018
$430k
NIA NIH HHS R01 AG074954NIA NIH HHS R21 AG058074
6 · The paper itself

Abstract

Amyloid β 42 (Aβ42) is an inherently disordered peptide, whose toxic actions are believed to play important roles in the etiology of Alzheimer's disease. Four fibril structures of the peptide that display broadly similar characteristics were recently published, but a systematic comparison of these structures is lacking. In this paper, a topological framework was created to enable such understanding and produced new insights into subtle structural elements that underlie the overall structural diversity. A DFT-based analysis illuminated some of the energetic differences that arise as a consequence.

Indexed as

Amyloid beta-PeptidesDensity Functional TheoryHumansModels, ChemicalPeptide FragmentsProtein ConformationAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide Fragmentsamyloid beta-peptidesfoldamershydrophobic interactionstopology

Identifiers

PMID30821034
PMCPMC6713286
OpenAlexW2918991276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.