Evidence map›Paper›PMID 30820999›Full record

ArticleJournal of veterinary internal medicine2019

Results of histopathology, immunohistochemistry, and molecular clonality testing of small intestinal biopsy specimens from clinically healthy client-owned cats.

Sina Marsilio, Mark R Ackermann, Jonathan A Lidbury, Jan S Suchodolski, Jörg M Steiner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

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  14. Simultaneous occurrence of inflammatory bowel disease and trichomonosis in a Maine coon cat - A comment.The Canadian veterinary journal = La revue veterinaire canadienne · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sina MarsilioGastrointestinal Laboratory, Texas A&M University, College Station, Texas.ORCID https://orcid.org/0000-0002-0693-0669
Mark R AckermannGastrointestinal Laboratory, Texas A&M University, College Station, Texas.
Jonathan A LidburyGastrointestinal Laboratory, Texas A&M University, College Station, Texas.ORCID https://orcid.org/0000-0001-5107-4577
Jan S SuchodolskiGastrointestinal Laboratory, Texas A&M University, College Station, Texas.
Jörg M SteinerGastrointestinal Laboratory, Texas A&M University, College Station, Texas.ORCID https://orcid.org/0000-0003-3336-2086
Texas A&M University · USOregon State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHistopathology, immunohistochemistry, and molecular clonality testing are metrics frequently used to diagnose chronic enteropathy (CE) in cats. However, normal values for these metrics have been based mainly on samples from cats that were relatively young, specific pathogen-free, or both.

objectivesTo describe results of histopathology, immunohistochemistry, and clonality testing of endoscopically-derived biopsy specimens of the upper small intestinal tract from a cohort of clinically healthy client-owned cats. ANIMALS: Twenty clinically healthy client-owned cats ≥3 years of age.

methodsTissue specimens were collected from the stomach and duodenum and evaluated single blinded by a board-certified pathologist. In addition, samples were evaluated by routine immunohistochemistry and clonality testing. Cats were followed after the procedure for signs of CE.

resultsIntegrated results from histopathology, immunohistochemistry, and clonality testing were interpreted as consistent with small cell lymphoma (SCL; n = 12), emerging SCL (n = 1), lymphocytic enteritis (n = 6), and pseudoclonality (n = 1). On follow-up, 3 cats eventually developed clinical signs of CE, of which 2 were euthanized 295 and 654 days post-endoscopy. The remaining 17 cats did not show clinical signs of CE after a median of 709 days (range, 219-869 days). CONCLUSIONS AND CLINICAL IMPORTANCE: Intestinal biopsy specimens from clinically healthy client-owned cats commonly had abnormal findings on histopathology, immunohistochemistry, clonality testing, or some combination of these without apparent clinical relevance. Current diagnostic metrics for diagnosing CE in cats may need modification to be applicable to the general population of cats.

Indexed as

AnimalsBiopsyCat DiseasesCatsClone CellsCohort StudiesEndoscopy, Digestive SystemEnteritisFemaleImmunohistochemistryIntestine, SmallMaleProspective StudiesReference Valuesfeline chronic enteropathyinflammatory bowel diseasePARRPCR for antigen receptor rearrangementssmall cell lymphoma

Identifiers

PMID30820999
PMCPMC6430868
OpenAlexW2919508667

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.