Evidence map›Paper›PMID 30820810›Full record

ArticleInvestigational new drugs2019

Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors.

Fei Tang, Eleftheria Tsakalozou, Susanne M Arnold, Chee M Ng, Markos Leggas

Abstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigational new drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fei Tang *Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, KY, 40536, USA.
Eleftheria Tsakalozou *Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, KY, 40536, USA.
Susanne M ArnoldDepartment of Internal Medicine, Division of Medical Oncology, Markey Cancer Center, University of Kentucky, 800 Rose St., Lexington, KY 40536, Lexington, KY, 40536, USA.
Chee M NgDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, KY, 40536, USA.
Markos LeggasDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone St., Lexington, KY, 40536, USA. mlegg2@email.uky.edu.ORCID http://orcid.org/0000-0003-4314-4533

Funding

Phase I and Biological Studies of DB67 - A Blood Stable CamptothecinR21CA123867 · NCI · UNIVERSITY OF KENTUCKY · PI LEGGAS, MARKOS · 2007 to 2008
$410k
NCI NIH HHS R21 CA123867
6 · The paper itself

Abstract

Background AR-67 is a novel camptothecin analogue at early stages of drug development. The phase 1 clinical trial in cancer patients with solid tumors was completed and a population pharmacokinetic model (POP PK) was developed to facilitate further development of this investigational agent. Methods Pharmacokinetic data collected in the phase 1 clinical trial were utilized for the development of a population POP PK by implementing the non-linear mixed effects approach. Patient characteristics at study entry were evaluated as covariates in the model. Subjects (N = 26) were treated at nine dosage levels (1.2-12.4 mg/m

Indexed as

Models, BiologicalAdultAgedAntineoplastic Agents, PhytogenicCamptothecinFemaleHumansMaleMiddle AgedNeoplasmsOrganosilicon Compounds7-tert-butyldimethylsilyl-10-hydroxycamptothecinAntineoplastic Agents, PhytogenicCamptothecinOrganosilicon CompoundsAR-67CamptothecinsPerformance statusPopulation pharmacokinetics

Identifiers

PMID30820810
PMCPMC6713628

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.