ReviewCurrent reviews in musculoskeletal medicine2019
Concussion Pathophysiology and Injury Biomechanics.
Review in Current reviews in musculoskeletal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05562232 (The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms - a Pilot Study Protocol), which is not on this map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms - a Pilot Study Protocol
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Nutritional interventions to support acute mTBI recovery.Frontiers in nutrition · 2022Pooled it
- The More, the Better: High-Dose Omega-3 Fatty Acids Improve Behavioural and Molecular Outcomes in Preclinical Models in Mild Brain Injury.Current neurology and neuroscience reports · 2021Pooled it
- Defining return-to-learn through an evidence-based systematic review.Frontiers in neurologyPooled it
- Transient effects of multi-infusion ketamine augmentation on treatment-resistant depressive symptoms in patients with treatment-resistant bipolar depression - An open-label three-week pilot study.Brain and behavior · 2020Trial
- Impaired Synaptic Plasticity in a Rodent Model of Intimate Partner Violence-Related Brain Injury.Hippocampus · 2026Article
- Position-dependent white matter microstructural differences in amateur soccer players: a multi-shell diffusion MRI study.Neuroradiology · 2026Article
- Article
- Respiratory modulation of neurophysiology and symptoms in athletes with sports-related concussion: a randomized crossover trial.Frontiers in neuroscience · 2026Article
- Probing Modulation of Attentional Correlates with Aerobic Exercise in Individuals with a History of Concussion.Brain sciences · 2025Article
- Sickness absence > 14 days following sport-related traumatic brain injuries: a nationwide register-based study in Sweden.BMC public health · 2025Article
- Psychiatric outcomes after mild concussion by treatment timing and age.Journal of psychiatric research · 2025Observational
- Average Biomechanical Responses of the Human Brain Grouped by Age and Sex.Annals of biomedical engineering · 2025Article
- Dietary Intake of n-3 Polyunsaturated Fatty Acids Prior to a Mild Traumatic Brain Injury Demonstrates a Dose-Response Effect for Neuroprotective Benefits in Male C57BL/6 Mice.Current developments in nutrition · 2025Article
- Beyond the Hit: The Hidden Costs of Repetitive Head Trauma.Neuroscience insights · 2025Review
- Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members.Clinical neurophysiology practice · 2025Article
- Synergistic label-free fluorescence imaging and miRNA studies reveal dynamic human neuron-glial metabolic interactions following injury.Science advances · 2024Article
- Functional Vision Questionnaire Detects Near Triad Impairments in Adolescent Athletes With Concussion History.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2024Article
- 18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired athletes.Journal of neurology · 2024Article
- Pathophysiology-Based Management of Secondary Injuries and Insults in TBI.Biomedicines · 2024Review
- Epidemiology, Pathophysiology, and Treatment Strategies of Concussions: A Comprehensive Review.Fortune journal of health sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe concussion public health burden has increased alongside our knowledge of the pathophysiology of mild traumatic brain injury (mTBI). The purpose of this review is to summarize our current understanding of mTBI pathophysiology and biomechanics and how these underlying principles correlate with clinical manifestations of mTBI. RECENT
findingsChanges in post-mTBI glutamate and GABA concentrations seem to be region-specific and time-dependent. Genetic variability may predict recovery and symptom severity while gender differences appear to be associated with the neuroinflammatory response and neuroplasticity. Ongoing biomechanical research has shown a growing body of evidence in support of an "individual-specific threshold" for mTBI that varies based on individual intrinsic factors. The literature demonstrates a well-characterized timeframe for mTBI pathophysiologic changes in animal models while work in this area continues to grow in humans. Current human research shows that these underlying post-mTBI effects are multifactorial and may correlate with symptomatology and recovery. While wearable sensor technology has advanced biomechanical impact research, a definitive concussion threshold remains elusive.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.