ArticleJournal of neurology2019
Aphasia outcome: the interactions between initial severity, lesion size and location.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effect of mobile application-based technology on post-stroke aphasia: a systematic review.Frontiers in neurology · 2024Pooled it
- Neural Resources Supporting Language Production vs. Comprehension in Chronic Post-stroke Aphasia: A Meta-Analysis Using Activation Likelihood Estimates.Frontiers in human neuroscience · 2021Pooled it
- Predicting Post-Stroke Aphasia Speech Performance from Multimodal Data with Explainable Machine Learning.bioRxiv : the preprint server for biology · 2026Article
- Digital Twin Model of Treatment Outcomes in Post-Stroke Aphasia.medRxiv : the preprint server for health sciences · 2026Article
- Multifactorial interplay on language recovery following left-hemispheric stroke: A retrospective study.Journal of neuropsychology · 2025Article
- Charting the Course of Aphasia Recovery: Factors, Trajectories, and Outcomes.Annual review of linguistics · 2025Article
- Disentangling neuroplasticity mechanisms in post-stroke language recovery.Brain and language · 2024Review
- Looking Upstream to Understand Race/Ethnicity as a Moderator for Poststroke Neuroinflammation and a Social Determinant for Poststroke Aphasia Outcomes.American journal of speech-language pathology · 2024Article
- Multivariate lesion symptom mapping for predicting trajectories of recovery from aphasia.Brain communications · 2024Article
- Distinct parallel activation and interaction between dorsal and ventral pathways during phonological and semantic processing: A cTBS-fMRI study.Human brain mapping · 2024Article
- Recovery from aphasia in the first year after stroke.Brain : a journal of neurology · 2023Article
- Interpretable deep learning for the prognosis of long-term functional outcome post-stroke using acute diffusion weighted imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Better long-term speech outcomes in stroke survivors who received early clinical speech and language therapy: What's driving recovery?Neuropsychological rehabilitation · 2022Article
- Time course of right-hemisphere recruitment during word production following left-hemisphere damage: A single case of young stroke.The European journal of neuroscience · 2022Article
- Multimodal Neural and Behavioral Data Predict Response to Rehabilitation in Chronic Poststroke Aphasia.Stroke · 2022Article
- Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy.Journal of stroke · 2022Review
- French Phonological Component Analysis and aphasia recovery: A bilingual perspective on behavioral and structural data.Frontiers in human neuroscience · 2022Article
- Brain age predicts long-term recovery in post-stroke aphasia.Brain communications · 2022Article
- Diagnosis and differential diagnosis flow diagram of Chinese post-stroke aphasia types and treatment of post-stroke aphasia.Aging medicine (Milton (N.S.W)) · 2021Review
- Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe outcome of aphasia at 3 months is variable in patients with moderate/severe stroke. The aim was to predict 3-month aphasia outcome using prediction models including initial severity in addition to the interaction between lesion size and location at the acute phase.
methodsPatients with post-stroke aphasia (assessed by the Aphasia Rapid Test at day 7-ART D7) and MRI performed at day 1 were enrolled (n = 73). Good outcome at 3-months was defined by an Aphasia Handicap Score of 0-2. Each infarct lesion was overlapped with an area of interest in the left temporo-parietal region to compute an intersection index (proportion of the critical region damaged by the infarct). We tested ART D7, age, lesion volume, and intersection index as well as a combined variable lesion volume*intersection in a univariate analysis. Then, we performed a multivariate analysis to investigate which variables were independent predictors of good outcome.
resultsART at D7, infarct volume, and the intersection index were univariate predictors of good outcome. In the multivariate analysis, ART D7 and "volume ≥ 50 ml or intersection index ≥ 20%" correctly classified 89% of the patients (p < 0.0001). When added to the model, the interaction between both variables was significant indicating that the impact of the size or site variable depends on the initial severity of aphasia.
conclusionIn patients with initially severe aphasia, large infarct size or critical damage in left temporoparietal junction is associated with poor language outcome at 3 months.
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Registered trials
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