ArticleHuman genetics2019
Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer.
Erratum issued Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Human genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.Nature genetics · 2023Pooled it
- Pooled it
- Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention.American journal of human genetics · 2026Article
- Systematic functional interrogation of genome-wide association studies locus 17p13.3 deciphered role and genetic control of FAM57A in colorectal cancer development.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024Article
- Exploring the Chemopreventive Effect of Medication on Gene Expression Linked to Colorectal Cancer: An Observational and Mendelian Randomization Analysis in Healthy Colon Mucosa.International journal of molecular sciences · 2024Observational
- Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges.Journal of nanobiotechnology · 2024Review
- A large-scale microRNA transcriptome-wide association study identifies two susceptibility microRNAs, miR-1307-5p and miR-192-3p, for colorectal cancer risk.Human molecular genetics · 2024Article
- Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation.Journal of the National Cancer Institute · 2024Article
- Genetic variants in hypoxia-inducible factor pathway are associated with colorectal cancer risk and immune infiltration.Journal of cellular and molecular medicine · 2024Article
- TRIM4 Expression Related to Malignant Progression and Cisplatin Resistance in Osteosarcoma.Applied biochemistry and biotechnology · 2024Article
- Emerging glyco-risk prediction model to forecast response to immune checkpoint inhibitors in colorectal cancer.Journal of cancer research and clinical oncology · 2023Article
- Proteomic Signature of Extracellular Vesicles Associated with Colorectal Cancer.Molecules (Basel, Switzerland) · 2023Article
- A Novel Approach to Staging and Detection of Colorectal Cancer in Early Stages.Journal of clinical medicine · 2023Article
- Association of HOTAIR rs2366152 and rs1899663 polymorphisms with colorectal cancer susceptibility in Iranian population: A case-control study.Journal of clinical laboratory analysis · 2023Article
- Identification of an energy metabolism-related six-gene signature for distinguishing and forecasting the prognosis of low-grade gliomas.Annals of translational medicine · 2023Article
- Benchmark study for evaluating the quality of reference genomes and gene annotations in 114 species.Frontiers in veterinary science · 2023Article
- Non-steroidal anti-inflammatory drugs and biomarkers: A new paradigm in colorectal cancer.Frontiers in medicine · 2023Review
- eQTL Set-Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Genomic landscape of colorectal carcinogenesis.Journal of cancer research and clinical oncology · 2022Review
- The Expression Quantitative Trait Loci in Immune Response Genes Impact the Characteristics and Survival of Colorectal Cancer.Diagnostics (Basel, Switzerland) · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
78 authors at 20 institutions in 14 countries.
Stephanie A BienDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. sbien@fredhutch.org.
Yu-Ru SuDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
David V ContiUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.
Tabitha A HarrisonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Conghui QuDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Xingyi GuoDivision of Epidemiology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
Yingchang LuDivision of Epidemiology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Paul L AuerJoseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53205, USA.
Barbara L BanburyDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Stéphane BézieauCentre Hospitalier Universitaire Hotel-Dieu, 44093, Nantes, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Daniel D BuchananCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
Bette J CaanDivision of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, CA, 94612, USA.
Peter T CampbellEpidemiology Research Program, American Cancer Society, Atlanta, GA, 30329-4251, USA.
Christopher S CarlsonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Jenny Chang-ClaudeUnit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Sai ChenDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
Charles M ConnollyDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Douglas F EastonDepartment of Public Health and Primary Care School of Clinical Medicine, University of Cambridge, Cambridge, England, 01223, UK.
Edith J M FeskensDivision of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
Steven GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, 1X5, Canada.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
Marc J GunterSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Jochen HampeMedical Department 1, University Hospital Dresden, TU Dresden, 01307, Dresden, Germany.
Jeroen R HuygheDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
Thomas J HudsonOntario Institute for Cancer Research, Toronto, ON, Canada.
Eric J JacobsEpidemiology Research Program, American Cancer Society, Atlanta, GA, 30329-4251, USA.
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
Ellen KampmanDivision of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
Hyun Min KangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sébastien KüryCentre Hospitalier Universitaire Hotel-Dieu, 44093, Nantes, France.
Flavio LejbkowiczClalit Health Services National Israeli Cancer Control Center, 34361, Haifa, Israel.
Loic Le MarchandUniversity of Hawai'i Cancer Center, Honolulu, Hawaii, 96813, USA.
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
Li LiDepartment of Family Medicine and Community Health, Case Western Reserve University, Cleveland, OH, 44106, USA.
Christopher I LiDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Annika LindblomDepartment of Clinical Genetics, Karolinska University Hospital Solna, 171 77, Stockholm, Sweden.
Noralane M LindorDepartment of Health Science Research, Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA.
Vicente MartínBiomedicine Institute (IBIOMED), University of León, León, Spain.
Caroline E McNeilUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.
Marilena MelasUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.
Victor MorenoCIBER Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.
Polly A NewcombDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Kenneth OffitDepartment of Medicine, Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Paul D P PharaohDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB2 1TN, UK.
John D PotterDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Chenxu QuUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.
Elio RiboliSchool of Public Health, Imperial College London, London, UK.
Gad RennertClalit Health Services National Israeli Cancer Control Center, 34361, Haifa, Israel.
Núria SalaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, 08908, Barcelona, Spain.
Clemens SchafmayerDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24118, Kiel, Germany.
Peter C ScacheriDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Stephanie L SchmitDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Inc, Tampa, FL, 33612, USA.
Gianluca SeveriCentre for Research in Epidemiology and Population Health, Institut de Cancérologie Gustave Roussy, Villejuif, France.
Martha L SlatteryDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Joshua D SmithDepartment Genome Sciences, University of Washington, 98195, Seattle, WA, USA.
Antonia TrichopoulouHellenic Health Foundation, 13 Kaisareias & Alexandroupoleos, 115 27, Athens, Greece.
Rosario TuminoAffiliation Cancer Registry, Department of Prevention, Azienda Sanitaria Provinciale di Ragusa, Ragusa, Italy.
Cornelia M UlrichPopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT, 84112, USA.
Fränzel J B van DuijnhovenDivision of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
Bethany Van GuelpenDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Emily WhiteDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet Solna, 17177, Stockholm, Sweden.
Michael O WoodsDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, Saint John's, NL, A1B 3V6, Canada.
Anna H WuUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.
Goncalo R AbecasisDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.
Graham CaseyCentre for Research in Epidemiology and Population Health, Institut de Cancérologie Gustave Roussy, Villejuif, France.
Deborah A NickersonDepartment Genome Sciences, University of Washington, 98195, Seattle, WA, USA.
Stephen B GruberUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA.
Li HsuDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Wei ZhengDivision of Epidemiology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
University of Virginia · USFred Hutch Cancer Center · USUniversity of Southern California · USHeidelberg University · DEThe University of Melbourne · AUUniversity of Toronto · CAUniversity of Washington · USAbbVie (United States) · USBrigham and Women's Hospital · USCancer Center of Hawaii · USCarmel Medical Center · ILCase Western Reserve University · USCentre Hospitalier Universitaire de Nantes · FRDivision of Cancer Epidemiology and GeneticsImperial College London · GBInstitut Català d'Oncologia · ESKaiser Permanente · USKarolinska University Hospital · SENational Cancer Institute · USTechnische Universität Dresden · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MTransdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MDetection of Colorectal Cancer Susceptibility Loci Using Genome-Wide SequencingU01CA164930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2012 to 2015
$12.4MUsing Functional Genomics to Inform Gene Environment Interactions for Colorectal CancerR01CA201407 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GAUDERMAN, WILLIAM JAMES, LE MARCHAND, LOIC · 2016 to 2020
$9.6MThe Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0MDiscovery and verification of novel biomarkers of colorectal cancer recurrenceR01CA189184 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2015 to 2020
$5.6MCancer Research UK 10119Cancer Research UK 14136Cancer Research UK 16561Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1NCI NIH HHS K05 CA152715NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA160356NCI NIH HHS R01 CA189184NCI NIH HHS R01 CA189532NCI NIH HHS R01 CA193677NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA204279NCI NIH HHS R01 CA207371NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA206110NCI NIH HHS U24 CA074794NIDDK NIH HHS P30 DK058404NIH HHS S10 OD020069
Abstract
Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects by modulating gene expression. The computational method PrediXcan uses cis-regulatory variant predictors to impute expression and perform gene-level association tests in GWAS without directly measured transcriptomes. In this study, we used reference datasets from colon (n = 169) and whole blood (n = 922) transcriptomes to test CRC association with genetically determined expression levels in a genome-wide analysis of 12,186 cases and 14,718 controls. Three novel associations were discovered from colon transverse models at FDR ≤ 0.2 and further evaluated in an independent replication including 32,825 cases and 39,933 controls. After adjusting for multiple comparisons, we found statistically significant associations using colon transcriptome models with TRIM4 (discovery P = 2.2 × 10
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideCase-Control StudiesColorectal NeoplasmsGene ExpressionGene Expression Regulation, NeoplasticGene FrequencyHumansPredictive Value of TestsPrognosisRisk Factors
Identifiers
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Read underepoch 390
Registered trials
NCT02328677ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.