ArticleInternational journal of bipolar disorders2019
Mortality rate trends in patients diagnosed with schizophrenia or bipolar disorder: a nationwide study with 20 years of follow-up.
Article in International journal of bipolar disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- All-cause and cause-specific mortality among people with bipolar disorder: a large-scale systematic review and meta-analysis.Molecular psychiatry · 2023Pooled it
- Neural correlates of impulsivity in bipolar disorder: A systematic review and clinical implications.Neuroscience and biobehavioral reviews · 2023Pooled it
- Bipolar disorder and the risk for stroke incidence and mortality: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Peripheral Blood-Based Gene Expression Studies in Schizophrenia: A Systematic Review.Frontiers in genetics · 2021Pooled it
- Trial
- Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal Positron Emission Tomography-Magnetic Resonance Imaging Study.Biological psychiatry · 2026Article
- Time Trends in Excess Mortality Among Individuals With Bipolar Disorder in Finland, 2000-2023: A Nationwide Register Study.Bipolar disorders · 2026Article
- Cardiovascular fitness of forensic psychiatric patients: a longitudinal clinical study.Annals of general psychiatry · 2026Article
- Long-term mortality and associated factors in first episode psychosis: a 25-year follow-up study.Psychological medicine · 2025Article
- Healthcare for individuals with schizophrenia in Taiwan: 10-year national trend analysis.BJPsych open · 2025Article
- Article
- A randomised controlled feasibility trial comparing culturally adapted psychoeducation and treatment as usual for persons with bipolar disorders in Nigeria.BJPsych open · 2025Article
- Time trends in life expectancy of people with severe mental illness in Scotland, 2000-2019: population-based study.BJPsych open · 2025Article
- Neuroethics and treatment without consent.CNS spectrums · 2025Article
- Neurobiological Mechanisms Link Bipolar Disorder to Cardiovascular Disease: A Retrospective Biobank Study of Adverse Event Risk and Contributory Mechanisms.Bipolar disorders · 2025Observational
- Factors associated with low fruit and vegetable consumption among people with severe mental ill health.Social psychiatry and psychiatric epidemiology · 2024Article
- General practitioners' experiences of providing somatic care for patients with severe mental illness: a qualitative study.BMC primary care · 2024Article
- Circulating Cell-Free Mitochondrial DNA in Plasma of Individuals with Schizophrenia and Cognitive Deficit in Mexican Population.Neuropsychiatric disease and treatment · 2024Article
- Disparities in cardiovascular disease and treatment in the Nordic countries.The Lancet regional health. Europe · 2023Review
- Physical health disparities and severe mental illness: A longitudinal comparative cohort study using hospital data in Northern Ireland.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with severe mental illness (SMI) have a reduced life expectancy of one to two decades as compared to the general population, with most years of life lost due to somatic diseases. Most previous studies on disorders constituting SMI, e.g. schizophrenia and bipolar disorder, have investigated the disorders separately and hence not compared the disorders in terms of mortality rates relative to the background population.
methodsA register-based cohort study including the entire Danish population comparing mortality rates relative to the background population, controlling for age and sex, i.e. standardized mortality ratios (SMRs) in patients diagnosed with schizophrenia with those in patients diagnosed with bipolar disorder, during the study period from 1995 to 2014.
resultsThe SMR of patients with SMI was significantly higher than one for each calendar year in the study period with an overall SMR of 4.58, 95% CI (4.48-4.69) in patients diagnosed with schizophrenia (n = 38,500) and of 2.57 (95% CI 2.49-2.65) in patients diagnosed with bipolar disorder (n = 23,092). When investigating time trends in SMR for schizophrenia and for bipolar disorder, respectively, an increase in SMR over time was shown with a mean increase of 0.03 per year for schizophrenia and 0.02 for bipolar disorder (p < 0.01 for both disorders). The ratio between SMR for schizophrenia and SMR for bipolar disorder for each calendar year over the study period was constant (p = 0.756).
conclusionsIncreasing SMRs over the last 20 years were found for both patients diagnosed with bipolar disorder and patients diagnosed with schizophrenia. Despite clear differences between the two disorders regarding SMRs, the increases in SMR over time were similar, which could suggest similar underlying factors influencing mortality rates in both disorders.
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