Evidence map›Paper›PMID 30820637›Full record

ReviewCurrent genetics2019

Stress-induced protein aggregates shape population heterogeneity in bacteria.

Julien Mortier, Wubishet Tadesse, Sander K Govers, Abram Aertsen

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Update on the Protein Homeostasis Network inFrontiers in microbiology · 2022
    Review
  5. Article
  6. Senescence in Bacteria and Its Underlying Mechanisms.Frontiers in cell and developmental biology · 2021
    Review
  7. Article
  8. Article
  9. Review
  10. Heat and Pressure Resistance inFrontiers in microbiology · 2020
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Julien MortierDepartment of Microbial and Molecular Systems (M²S), KU Leuven, 3001, Leuven, Belgium.
Wubishet TadesseDepartment of Microbial and Molecular Systems (M²S), KU Leuven, 3001, Leuven, Belgium.
Sander K GoversDepartment of Microbial and Molecular Systems (M²S), KU Leuven, 3001, Leuven, Belgium.
Abram AertsenDepartment of Microbial and Molecular Systems (M²S), KU Leuven, 3001, Leuven, Belgium. abram.aertsen@kuleuven.be.ORCID http://orcid.org/0000-0002-1897-2305
KU Leuven · BEYale University · US

Funding

Agentschap voor Innovatie door Wetenschap en Technologie PhD FellowshipOnderzoeksraad, KU Leuven IDO/10/012 and DBOF/14/049Research Foundation Flanders G058011N and G0C7118NResearch Foundation Flanders PhD Fellowship
6 · The paper itself

Abstract

The concept of phenotypic heterogeneity preparing a subpopulation of isogenic cells to better cope with anticipated stresses has been well established. However, less is known about how stress itself can drive subsequent cellular individualization in clonal populations. In this perspective, we focus on the impact of stress-induced cellular protein aggregates, and how their segregation and disaggregation can act as a deterministic incentive for heterogeneity in the population emerging from a stressed ancestor.

Indexed as

Genetic HeterogeneityEscherichia coliProtein AggregatesStress, PhysiologicalProtein AggregatesAsymmetric segregationEpigenetic memoryEscherichia coliPhenotypic heterogeneityProtein aggregatesStress resistance

Identifiers

PMID30820637
OpenAlexW2920411283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.