ArticlePsychopharmacology2019
Functional characterization of the cannabinoid receptors 1 and 2 in zebrafish larvae using behavioral analysis.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Early Life Exposure to ΔCannabis and cannabinoid research · 2025Article
- doc2a and doc2b contribute to locomotor and social behaviors by down-regulating npas4b in zebrafish.BMC biology · 2025Article
- A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment.Biomedicines · 2022Review
- The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns.Current neuropharmacology · 2022Article
- Detailed Analysis of Zebrafish Larval Behaviour in the Light Dark Challenge Assay Shows That Diel Hatching Time Determines Individual Variation.Frontiers in physiology · 2022Article
- In Vivo Evaluation ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Clinical characteristics of COVID-19 patients evaluated in the emergency department: A retrospective cohort study of 801 cases.Journal of the American College of Emergency Physicians open · 2021Article
- Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARγ in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Medium-throughput zebrafish optogenetic platform identifies deficits in subsequent neural activity following brief early exposure to cannabidiol and ΔScientific reports · 2021Article
- Cannabinoids modulate associative cerebellar learning via alterations in behavioral state.eLife · 2020Article
- Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model.Frontiers in pharmacology · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe endocannabinoid system (ECS) comprises the cannabinoids anandamide and 2-arachidonoylglycerol and the cannabinoid receptors 1 and 2 (Cnr1 and Cnr2). The function of these receptors in relation to zebrafish larval behavior is poorly understood, even though the zebrafish larva has become a versatile animal model in biomedical research.
objectivesThe objective of the present study is to characterize the function of Cnr1 and Cnr2 in relation to behavior in zebrafish.
methodsBehavioral analysis of zebrafish larvae was performed using a visual motor response (VMR) test, which allows locomotor activity to be determined under basal conditions and upon a dark challenge.
resultsTreatment with the non-specific Cnr agonists WIN55,212-2 and CP55,940 resulted in a decrease in locomotion. This was observed for both basal and challenge-induced locomotion, although the potency for these two effects was different, which suggests different mechanisms of action. In addition, WIN55,212-2 increased the reaction time of the startle response after the dark challenge. Using the Cnr1 antagonist AM251 and a cnr1
conclusionsTaken together, these results show that Cnr1 activation by exogenous endocannabinoids modulates both basal and challenge-induced locomotor activity in zebrafish larvae and that these behavioral effects can be used as a readout to monitor the Cnr1 responsiveness in the zebrafish larva model system.
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