ArticleThe journal of nutrition, health & aging2019
Serum SIRT1 Is Associated with Frailty and Adipokines in Older Adults.
Article in The journal of nutrition, health & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Molecular Variants inInternational journal of women's health · 2025Article
- SIRT1 Serum Concentrations in Lipodystrophic Syndromes.International journal of molecular sciences · 2024Article
- Sirtuin 1 serum concentration in healthy children - dependence on sex, age, stage of puberty, body weight and diet.Frontiers in endocrinology · 2024Article
- The causal association between circulating cytokines with the risk of frailty and sarcopenia under the perspective of geroscience.Frontiers in endocrinology · 2024Article
- The Role of Sirtuins in Sarcopenia and Frailty.Aging and disease · 2023Article
- Biomarkers of Frailty: miRNAs as Common Signatures of Impairment in Cognitive and Physical Domains.Biology · 2022Review
- Monoterpenes as Sirtuin-1 Activators: Therapeutic Potential in Aging and Related Diseases.Biomolecules · 2022Review
- Frailty in China: From Research to Practice.The journal of nutrition, health & aging · 2021Review
- Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management.Frontiers in nutrition · 2021Review
- Understanding the Physiological Links Between Physical Frailty and Cognitive Decline.Aging and disease · 2020Review
- ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty.The Journal of frailty & aging · 2020Article
- Reliability and validity of the self-reported frailty screening questionnaire in older adults.Therapeutic advances in chronic disease · 2020Article
- Correlation Between Serum and Tissue SIRT1 Levels in Patients With Esophageal Squamous Cell Carcinoma.Cancer diagnosis & prognosisArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBecause frailty is a major health concern among older patients, identifying frailty-related biomarkers will help in the early detection and prevention of frailty. Thus, we aimed to determine the association between circulating levels of silent mating-type information regulation 2 homolog 1 (SIRT1) and frailty.
methodsWe assessed circulating SIRT1 levels in 16 robust, 74 prefrail, and 40 frail older adults. Frailty was diagnosed based on the Fried phenotype. Circulating cytokine and adipokine (e.g., vaspin, adiponectin, and leptin) levels were assessed. Differences in SIRT1 levels among the three subject groups were compared; correlations of SIRT1 levels with physical function and adipokine and cytokine levels were analyzed.
resultsSerum SIRT1 levels were significantly higher among frail older adults than among robust ones. Older adults with slowness or weight loss had high SIRT1 levels. Serum SIRT1 levels negatively correlated with gait speed, even after adjustment for age and sex; age; and insulin, vaspin, and leptin levels; they correlated negatively with phospholipase A2 levels.
conclusionsHigh SIRT1 levels were observed in frail elderly patients and were correlated with decreased physical function. Insulin and adipokine levels might be the link between SIRT1 and frailty, whereas inflammation may not be involved in this process.
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