ArticleThe journal of nutrition, health & aging2019
Evaluation of Oxidative Stress Parameters and Antioxidant Status in Plasma and Erythrocytes of Elderly Diabetic Patients with Sarcopenia.
Article in The journal of nutrition, health & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Factors associated with sarcopenia in elderly patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Pooled it
- Review
- The association between time in range with sarcopenia and its components in older patients with type 2 diabetes mellitus.Scientific reports · 2026Article
- Pathological changes and therapeutic strategies for sarcopenia.EFORT open reviews · 2026Review
- Development of a machine learning model for predicting pre-sarcopenia in adults with abdominal obesity: a cross-sectional study.Journal of endocrinological investigation · 2026Article
- Association of serum chitinase-3-like protein 1 with sarcopenia in patients with type 2 diabetes mellitus.Journal of endocrinological investigation · 2025Article
- Associations of dietary oxidative balance score with sarcopenia in adults: an NHANES-based cross-sectional study.Nutrition & metabolism · 2025Article
- Physical frailty is related to oxidative stress through thiol/disulfide homeostasis parameters.European geriatric medicine · 2024Article
- Association between oxidative balance score and sarcopenia in older adults.Scientific reports · 2024Article
- Association of Questionnaire-Based Physical Activity Analysis and Body Composition Dynamics in Type 2 Diabetes: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Bioelectrical Impedance Analysis for the Assessment of Body Composition in Sarcopenia and Type 2 Diabetes.Nutrients · 2022Review
- The relationship of dietary total antioxidant capacity with sarcopenia and cardiometabolic biomarkers in type 2 diabetes patients.Physiological reports · 2022Article
- Sedentary lifestyle and body composition in type 2 diabetes.Diabetology & metabolic syndrome · 2022Article
- Pro-Aging Effects of Xanthine Oxidoreductase Products.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOxidative stress may play a role in the pathogenesis of both sarcopenia and diabetes. Although the risk of sarcopenia is increased in people with type 2 diabetes, the relationship between sarcopenia oxidative stress and antioxidant status among the older diabetes population is not well studied. The aim of this present study was to evaluate the relationship between oxidative stress and antioxidant status and sarcopenia in elderly diabetic patients.
designThis was a cross-sectional designed study with a control group. A total of 60 type 2 diabetic elderly patients were enrolled in the study (30 sarcopenic and 30 controls). MEASUREMENTS: Comprehensive geriatric assessments and anthropometric measurements were performed. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People. Skeletal muscle mass was measured using bioelectrical impedance analysis. A handheld dynamometer was used for skeletal muscle strength measurements. Gait speed was measured using a 4 meter walking test. Plasma malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and erythrocyte MDA, GSH-Px, superoxide dismutase (SOD), catalase and xanthine oxidase (XO) measurements were performed.
resultsWhile plasma XO was significantly higher in sarcopenic individuals (0.406(0.225-0.775)) compared to controls (0.312(0.112-0.712)) (p=0.006), plasma GSH-Px was significantly lower in sarcopenic individuals (0.154(0.101-0.274)) compared to controls (0.204(0.12-.0312)) (p=0.003). Plasma XO (OR: 2.69 (CI 95% 0.13-52.76, p=0.041) and BMI (OR: 0.6 (CI 95% 0.41-0.89, p=0.009) were independently associated with sarcopenia of diabetes in multivariate analysis.
conclusionsOnly plasma XO was found to be independently associated with sarcopenia. XO can be important in the pathogenesis of sarcopenia in diabetes. Oxidative stress and antioxidant status might be associated with sarcopenia in diabetic older individuals but this association seems to be mediated by other factors. Further studies are needed on this subject.
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