ArticleCommunications biology2019
Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04292444 (Disentangling Effects of Oxytocin on Cognitive and Reactive Fear and the Moderating Role of the Receptor for Advanced Glycation End-products), which is not on this map. Cited by 83 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 2 pooled it
31.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Disentangling Effects of Oxytocin on Cognitive and Reactive Fear and the Moderating Role of the Receptor for Advanced Glycation End-products
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Maternal and newborn plasma oxytocin levels in response to maternal synthetic oxytocin administration during labour, birth and postpartum - a systematic review with implications for the function of the oxytocinergic system.BMC pregnancy and childbirth · 2023Pooled it
- Oxytocin and postpartum depression: A systematic review.Psychoneuroendocrinology · 2020Pooled it
- Trial
- Nasal dominance potentiates intranasal oxytocin's anxiolytic effects.Scientific reports · 2025Trial
- Plasma pharmacokinetics of intravenous and intranasal oxytocin in nonpregnant adults.British journal of anaesthesia · 2025Trial
- Oxytocin modulates local topography of human functional connectome in healthy men at rest.Communications biology · 2021Trial
- Oxytocin Affects Barriergenesis in the Blood-Brain Barrier and the Blood-Cerebrospinal Fluid Barrier In Vitro Monoculture Transwell Models.Developmental neurobiology · 2026Article
- Intranasal Vasopressin Decreases Voluntary Ethanol Drinking in Single- and Group-Housed Mice Through Mechanisms Involving Vasopressin 1a and 1b Receptors.Alcohol, clinical & experimental research · 2026Article
- Medical induction of maternal behavior in nurse mares and foal-rejecting mares undergoing foal grafting: a retrospective study of 140 cases.Journal of veterinary internal medicine · 2026Article
- Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The oxytocin system mediates behavioral and neurobiological alterations associated with early adversity.Molecular psychiatry · 2026Article
- ZFP57 is a regulator of postnatal growth and life-long health.Nature communications · 2026Article
- Increase in Comforting Behavior (Allogrooming) During Social Interaction in Male Mice Deficient for theBrain sciences · 2026Article
- Decoding RAGE in diabetes: a pathogenic signaling hub modulated by decoy receptors in diabetic complications.Frontiers in clinical diabetes and healthcare · 2026Review
- Oxytocin modulation of the insular cortex: implications for social cognition and neurodevelopmental disorders.Frontiers in neural circuits · 2026Review
- Repetitive daily oxytocin treatment reduces weight gain but not acute neonatal procedural pain.Pediatric research · 2025Article
- Oxytocin and opioid antagonists: A dual approach to improving social behavior.Annals of the New York Academy of Sciences · 2025Review
- Salivary and blood plasma oxytocin after oxytocin injection and during machine milking in dairy cows.JDS communications · 2025Article
- Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring.The Journal of veterinary medical science · 2025Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 6 institutions in 3 countries.
Yasuhiko YamamotoDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan. yasuyama@med.kanazawa-u.ac.jp.
Mingkun LiangDepartment of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Seiichi MunesueDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Kisaburo DeguchiMedical Research Institute, Kanazawa Medical University and Medical Care Proteomics Biotechnology Co., Uchinada, Ishikawa, 920-0293, Japan.
Ai HarashimaDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Kazumi FuruharaDepartment of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Teruko YuhiDepartment of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Jing ZhongDepartment of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Shirin AktherDepartment of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Hisanori GotoDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Yuya EguchiDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Yasuko KitaoDepartment of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Osamu HoriDepartment of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Yoshitake ShiraishiDepartment of Functional Anatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Noriyuki OzakiDepartment of Functional Anatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Yu ShimizuDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Tomoya KamideDepartment of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Akifumi YoshikawaDepartment of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Yasuhiko HayashiDepartment of Neurosurgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Mitsutoshi NakadaDepartment of Neurosurgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Olga LopatinaDepartment of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Maria GerasimenkoDepartment of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Yulia KomlevaLaboratory for Social Brain Studies, Research Institute of Molecular Medicine and Pathobiochemistry, and Department of Biochemistry, Krasnoyarsk State Medical University, Krasnoyarsk, Russia, 660022.
Natalia MalinovskayaLaboratory for Social Brain Studies, Research Institute of Molecular Medicine and Pathobiochemistry, and Department of Biochemistry, Krasnoyarsk State Medical University, Krasnoyarsk, Russia, 660022.
Alla B SalminaDepartment of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan.
Masahide AsanoDivision of Transgenic Animal Science, Kanazawa University Advanced Science Research Centre, Kanazawa, 920-8640, Japan.
Katsuhiko NishimoriLaboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, 981-8555, Japan.
Steven E ShoelsonJoslin Diabetes Centre & Harvard Medical School, Boston, MA, 02215, USA.
Hiroshi YamamotoDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 920-8640, Japan.
Haruhiro HigashidaDepartment of Basic Research on Social Recognition and Memory, Research Centre for Child Mental Development, Kanazawa University, Kanazawa, 920-8640, Japan. haruhiro@med.kanazawa-u.ac.jp.
Kanazawa University · JPKrasnoyarsk State Medical University · RUHarvard University · USKanazawa Medical University · JPKomatsu University · JPTohoku University · JP
Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5MNIDDK NIH HHS P30 DK036836
Abstract
Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal bonding behaviours. Mice lacking secreted oxcytocin (
Indexed as
Object AttachmentAnimalsBrainEndothelial CellsFemaleHumansMaleMaternal BehaviorMice, Inbred C57BLMice, KnockoutMice, TransgenicOxytocinReceptor for Advanced Glycation End ProductsReceptors, OxytocinOxytocinReceptor for Advanced Glycation End ProductsReceptors, Oxytocin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT04292444ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.