ArticleOptica2018
Dichroism-sensitive photoacoustic computed tomography.
Article in Optica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Revealing hidden tissue architecture with mid-infrared dichroism photoacoustic microscopy.Light, science & applications · 2026Article
- Deep tissue sensing of chiral molecules using polarization-enhanced photoacoustics.Science advances · 2025Article
- Dichroism-sensitive photoacoustic imaging for in-depth estimation of the optic axis in fibrous tissue.Photoacoustics · 2025Article
- Challenges and advances in two-dimensional photoacoustic computed tomography: a review.Journal of biomedical optics · 2024Review
- Adaptive polarization photoacoustic computed tomography for biological anisotropic tissue imaging.Photoacoustics · 2023Article
- Azimuth mapping of fibrous tissue in linear dichroism-sensitive photoacoustic microscopy.Photoacoustics · 2023Article
- Application of photoacoustic computed tomography in biomedical imaging: A literature review.Bioengineering & translational medicine · 2023Review
- Multiscale photoacoustic tomography of neural activities with GCaMP calcium indicators.Journal of biomedical optics · 2022Article
- Optical fiber-based handheld polarized photoacoustic computed tomography for detecting anisotropy of tissues.Quantitative imaging in medicine and surgery · 2022Article
- Polarized photoacoustic microscopy based on high-order harmonics for anisotropy detection.Annals of translational medicine · 2022Article
- Snapshot photoacoustic topography through an ergodic relay of optical absorption in vivo.Nature protocols · 2021Article
- Single-shot linear dichroism optical-resolution photoacoustic microscopy.Photoacoustics · 2019Article
- Enhanced contrast acoustic-resolution photoacoustic microscopy using double-stage delay-multiply-and-sum beamformer for vasculature imaging.Journal of biophotonics · 2019Article
- Photoacoustic imaging in the second near-infrared window: a review.Journal of biomedical optics · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Photoacoustic computed tomography (PACT), a fast-developing modality for deep tissue imaging, images the spatial distribution of optical absorption. PACT usually treats the absorption coefficient as a scalar. However, the absorption coefficients of many biological tissues exhibit an anisotropic property, known as dichroism or diattenuation, which depends on molecular conformation and structural alignment. Here we present a novel imaging method called dichroism-sensitive PACT (DS-PACT), which measures both the amplitude of tissue's dichroism and the orientation of the optic axis of uniaxial dichroic tissue. By modulating the polarization of linearly polarized light and measuring the alternating signals through lock-in detection, DS-PACT can boost dichroic signals from biological tissues. To validate the proposed approach, we experimentally demonstrated the performance of DS-PACT by imaging plastic polarizers and ex vivo bovine tendons deep inside scattering media. We successfully detected the orientation of the optic axis of uniaxial dichroic materials, even at a depth of 4.5 transport mean free paths. We anticipate that the proposed method will extend the capability of PACT to imaging tissue absorption anisotropy.
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Registered trials
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