Evidence map›Paper›PMID 30820345›Full record

ArticleFuture science OA2019

Use of amantadine as substrate for SSAT-1 activity as a reliable clinical diagnostic assay for breast and lung cancer.

Andrew W Maksymiuk, Paramjit S Tappia, Daniel S Sitar, Parveen S Akhtar, Nazrina Khatun, Rahnuma Parveen, Rashiduzzaman Ahmed, Rashid Bux Ahmed, Brian Cheng, Gina Huang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Future science OA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Association between Spermidine/Spermine NInternational journal of molecular sciences · 2022
    Review
  5. Article
  6. Current and Future Development in Lung Cancer Diagnosis.International journal of molecular sciences · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Andrew W MaksymiukCancer Care Manitoba, Winnipeg, MB, R3E 0V9, Canada.
Paramjit S TappiaClinical Research Institute & Office of Clinical Research, St Boniface Hospital, Winnipeg, MB, R2H 2A6, Canada.
Daniel S SitarDepartment of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3A 1R9, Canada.
Parveen S AkhtarDepartment of Medical Oncology, National Institute of Cancer Research & Hospital, Mohakhali, Dhaka, Bangladesh.
Nazrina KhatunDepartment of Medical Oncology, National Institute of Cancer Research & Hospital, Mohakhali, Dhaka, Bangladesh.
Rahnuma ParveenDepartment of Medical Oncology, National Institute of Cancer Research & Hospital, Mohakhali, Dhaka, Bangladesh.
Rashiduzzaman AhmedFastBios, Dhaka, Bangladesh.
Rashid Bux AhmedBioMark Diagnostics Inc., Richmond, BC, V6X 2W8, Canada.
Brian ChengBioMark Diagnostics Inc., Richmond, BC, V6X 2W8, Canada.
Gina HuangBioMark Diagnostics Inc., Richmond, BC, V6X 2W8, Canada.
Horacio BachDivision of Infectious Diseases, Faculty of Medicine, University of British Columbia, Vancouver, BC, V5Z 3J5, Canada.
Brett HiebertCardiac Sciences Program, Asper Clinical Research Institute, Winnipeg, MB, R2H 2A6, Canada.
Bram RamjiawanClinical Research Institute & Office of Clinical Research, St Boniface Hospital, Winnipeg, MB, R2H 2A6, Canada.
National Institute of Cancer Research and Hospital · BDUniversity of Manitoba · CACancerCare Manitoba · CASt. Boniface Hospital · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimSpermidine/spermine N

resultsAn increase in the urinary concentration of AA in lung and breast cancer patients was observed. The 0-2 h collection time point was determined to be optimal in revealing significant differences in urinary AA concentration between healthy controls and cancer patients.

conclusionThe high urine concentration of AA could be used as a simple and useful test for the detection of breast and lung cancer.

Indexed as

amantadinebiomarkersbreast cancercancer diagnostics and screeninglung cancerpolyamine metabolismSSAT-1

Identifiers

PMID30820345
PMCPMC6391627
OpenAlexW2904549627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.