ArticleClinical and translational allergy2019
Sensitivity and specificity of standardised allergen extracts in skin prick test for diagnoses of IgE-mediated respiratory allergies.
Article in Clinical and translational allergy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
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- Inhaled Allergy Diagnostics and Treatment in a Polluted Environment.International journal of molecular sciences · 2025Review
- Monitoring, distribution and clinical relevance of airborne pollen and fern spores in Southeast Asia - A systematic review.The World Allergy Organization journal · 2025Review
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- Diagnostics of Allergy to Furry Animals-Possibilities in 2024.Journal of clinical medicine · 2024Review
- Agreement of Peru-Based Allergy Tests for Respiratory Allergens in Allergic Rhinitis Patients.Journal of immunology research · 2024Article
- Allergy screening with extract-based skin prick tests demonstrates higher sensitivity over in vitro molecular allergy testing.Clinical and translational allergy · 2023Article
- Minimum number and types of allergens for a skin prick test panel in Thai children with allergic respiratory diseases.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
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- Highlights and recent developments in allergic diseases in EAACI journals (2019).Clinical and translational allergy · 2020Review
- The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants.The World Allergy Organization journal · 2020Article
- Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens.Clinical and translational allergy · 2020Article
- Medical devices in allergy practice.The World Allergy Organization journal · 2020Review
- Design of an Optimally-Diagnostic Skin Test for Diagnosis of Sensitivity to Eight Allergens: A First-in-Human Study of Dose Escalation and Simultaneous Administration in Chinese Subjects.Journal of asthma and allergy · 2020Article
- Minimizing the Number of Aeroallergen Extracts in Skin Prick Test in IgE-Mediated Allergic Disorders in Both Adults and Children in Jordan.Journal of asthma and allergy · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkin prick tests (SPTs) are essential for the diagnosis of IgE-mediated allergy and are influenced by extract quality, biological potency and concentration of allergen.
methodsIn this open multicentre study 431 patients, aged 18-64 years were enrolled. Patients had a history of IgE-mediated allergy and a sensitisation (previous positive SPT of any manufacturer) against at least one of the investigated allergens: 6-grass pollen, house dust mite, birch and mugwort pollen. In our study, these allergens were tested in five concentrations each. To establish the optimal trade-off between sensitivity and specificity, the area under the receiver operating characteristic (ROC) curve was estimated by comparing the outcome of the SPT with three methods referred to as 'reference methods' (specific IgE, clinical case history and a previous SPT).
resultsFor all allergens and reference methods, the area under the ROC curves were highly significant (p < 0.001). Specific IgE reference method resulted in the largest area under the curve (AUC) for all allergens (0.80-0.90) followed by previous SPT (0.70-0.87) and case history (0.65-0.74). Sensitivity of SPT increased with increasing concentration and specificity decreased. For all allergens, compared to specific IgE, the highest sensitivity (specificity at least 80%) was observed for the SPT solution of 50,000 Standardised Units (SU)/mL (grass pollen, birch pollen, house dust mite and mugwort).
conclusionIn this study, with a large number of patients, it was demonstrated that clinical case history, previous SPT and specific IgE measurement could all be used as reference methods for the assessment of sensitivity/specificity of SPT solutions. The comparison of SPT with specific IgE resulted in the largest AUC. The highest sensitivity was observed for the SPT solution of 50,000 SU/mL.
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