Evidence map›Paper›PMID 30820139›Full record

ArticleMolecular vision2018

Human lens weights with increasing age.

Ashik Mohamed, Robert C Augusteyn

Abstract read
In one paragraph

Article in Molecular vision, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Global challenges for lens and cataract research.Frontiers in ophthalmology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ashik MohamedOphthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India.
Robert C AugusteynBrien Holden Vision Institute, Sydney, Australia.

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Optics of the Growing Crystalline LensR01EY021834 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MANNS, FABRICE · 2012 to 2016
$2.3M
NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY021834
6 · The paper itself

Abstract

Purpose: To evaluate the changes with age in human lens wet and dry weights. Methods: All procedures were performed by the same person in the same environment. Lenses were extracted from donor eyes within a median post-mortem time of 22 h, blotted dry and weighed within 30 min, immediately placed in fixative for 1 week, and then dried at 80 °C until a constant weight was achieved. Results: Wet and dry lens weights were obtained from 549 human lenses. Before age 2 years, most of the weight increases are due to a self-limiting process and can be described with logistic equations. The maximum asymptotic wet and dry weights for male lenses are 6.0 and 1.77 mg, respectively, heavier than those for female lenses. After age 3 years, male and female lens weights increase at the same linear rate. Conclusions: The data support the biphasic growth model for human lenses. Male lenses are significantly larger than female lenses at the conclusion of the prenatal growth mode, but the rate of weight accrual is constant thereafter. Lens weights increase continuously throughout life and can be described with equations that incorporate terms for prenatal and postnatal growth.

Indexed as

AdolescentAdultAgedAged, 80 and overAgingChildChild, PreschoolFemaleHumansInfantInfant, NewbornLens, CrystallineMaleMiddle AgedOrgan SizeTissue Donors

Identifiers

PMID30820139
PMCPMC6382474

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.