ArticleInternational journal of trichology
Serum Interleukin-15 is a Marker of Alopecia Areata Severity.
Article in International journal of trichology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05910138 (Evaluation of Serum Levels of Interlukin-15 and Interlukin-21 in Patients With Alopecia Areata), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Serum Levels of Interlukin-15 and Interlukin-21 in Patients With Alopecia Areata
Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Chemotherapy-Induced Alopecia Beyond Cytotoxicity: Hair Follicle Immune Privilege Collapse and JAK-STAT Signaling.International journal of molecular sciences · 2026Review
- Hypoxia and IL-15 Cooperate to Induce Perforin Expression by CD8 T Cells and Promote Damage to the Skin in Murine Cutaneous Leishmaniasis.The Journal of investigative dermatology · 2025Article
- The molecular puzzle of autoinflammatory skin diseases-a review of chosen conditions.Journal of applied genetics · 2025Review
- Review
- Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata.Frontiers in pharmacology · 2025Article
- Article
- Inhibition of T-cell activity in alopecia areata: recent developments and new directions.Frontiers in immunology · 2023Review
- Interleukin-15 and Tumor Necrosis Factor-Dermatology research and practice · 2023Article
- Inflammatory loops in the epithelial-immune microenvironment of the skin and skin appendages in chronic inflammatory diseases.Frontiers in immunology · 2023Review
- Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases.Journal of immunology research · 2023Article
- The current state of knowledge of the immune ecosystem in alopecia areata.Autoimmunity reviews · 2022Review
- An overview of JAK/STAT pathways and JAK inhibition in alopecia areata.Frontiers in immunology · 2022Review
- Immunopathogenesis of alopecia areata.Current research in immunology · 2021Review
- Alopecia Areata: An Autoimmune Disease of Multiple Players.ImmunoTargets and therapy · 2021Review
- Serum level of interleukin-15 in active alopecia areata patients and its relation to age, sex, and disease severity.Postepy dermatologii i alergologii · 2020Article
- Evaluation of the level of serum Interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with disease severity in patients with alopecia areata.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin-15 (IL-15) is a cytokine that is involved in many inflammatory and autoimmune diseases. Although alopecia areata (AA) is an autoimmune disease, serum levels of IL-15 have not been studied well in AA patients. AIM OF THE WORK: We aims at evaluating the serum levels of IL-15 in active AA. SUBJECT AND
methodsThis case-control study included 40 AA patients and 40 apparently healthy matched controls. Written informed consents were obtained from all the participants. The scalp was examined to assess sites, number, and size of alopecia patches, and the severity of AA lesions was assessed using the Severity of Alopecia Tool score (SALT score) which determine the percentage of hair loss in the scalp. The body was carefully examined to detect any alopecia patches in any hairy area. Nail examination was carried out to detect any nail involvement. Serum IL-15 levels were measured using an ELISA kits.
resultsSerum levels of IL-15 in patients were significantly higher than those in the control group (
conclusionSerum IL-15 may be a marker of AA severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.