ArticleJournal of conservative dentistry : JCD
Effect of pretreatment medication on postendodontic pain: A double-blind, placebo-controlled study.
Article in Journal of conservative dentistry : JCD. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03998826 (Effect of Piroxicam Premedication on Postendodontic Pain in Mandibular Molars With Non-vital Pulp), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Piroxicam Premedication on Postendodontic Pain in Mandibular Molars With Non-vital Pulp: A Randomized Controlled Trial
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Therapeutic management of dexamethasone in patients undergoing endodontics: a randomized clinical trial.Odontology · 2026Trial
- Effect of sublingual fast-dissolving piroxicam premedication on postoperative pain experience in mandibular molars with non-vital pulp: a randomized double-blind controlled trial.Head & face medicine · 2024Trial
- Effect of a Single Dose of Deflazacort on Postoperative Pain, Swelling, and Trismus after Impacted Lower Third Molar Surgery: Randomised Clinical Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Can instrumentation kinematics affect postoperative pain and substance P levels? A randomized controlled trial.BMC oral health · 2024Trial
- The Effect of Reciprocating Instrument and Root Canal Filling Techniques on Post-operative Pain in Retreatment: A Prospective Clinical Study.European endodontic journal · 2023Trial
- Comparative Evaluation of Preemptive and Preventive Analgesic Effect of Oral Ibuprofen in Single Visit Root Canal Treatment- A Prospective Randomised Pilot Study.European endodontic journal · 2022Trial
- Effectiveness and Safety of Pretreatment Analgesics and Anti-Inflammatory Drugs in Endodontic Pain Management: Overview of Systematic Reviews.International journal of dentistry · 2026Review
- Efficacy of NSAIDs and corticosteroids as premedication for post-endodontic pain management: A systematic review and meta-analysis.Journal of clinical and experimental dentistry · 2025Review
- Impact of calcium hydroxide as an intracanal medicament on postoperative pain in diabetic and non-diabetic patients with symptomatic apical periodontitis and pulp necrosis - a double-blind randomized controlled clinical trial.Journal of clinical and experimental dentistry · 2025Review
- Comparative Effects of Premedication with Ibuprofen and Essential Oil of Urtica Dioica on Post-Endodontic Pain: Clinical Trial.Journal of dentistry (Shiraz, Iran) · 2024Article
- Can postanesthetic cold sensibility test be used as a tool for the efficacy of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis of mandibular molars? -Journal of conservative dentistry and endodontics · 2024Article
- Endodontic Flare-Ups: An Update.Cureus · 2023Review
- Experimental study of dexamethasone-loaded hollow hydroxyapatite microspheres applied to direct pulp capping of rat molars.Frontiers in endocrinology · 2023Article
- Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: 3-Dimensional Analysis Using Cone-Beam Computed Tomography on the Outcomes of Non-Surgical Endodontic Treatment Using A-PRF+ and Calcium Hydroxide: A Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Endodontic postoperative flare-up: An update.The Saudi dental journal · 2021Review
- Effect of premedication on postoperative pain after root canal therapy in patients with irreversible pulpitis: a systematic review and meta-analysis.Journal of dental anesthesia and pain medicine · 2021Review
- Dexamethasone caution.British dental journal · 2020Article
- Antibiotic abuse during endodontic treatment: A contributing factor to antibiotic resistance.Journal of family medicine and primary care · 2019Review
- Evaluation of postoperative pain using warm versus room temperature sodium hypochlorite as an irrigant in mandibular molars with irreversible pulpitis: A randomized controlled trial.Journal of conservative dentistry and endodonticsArticle
- Analgesic efficacy of corticosteroids and nonsteroidal anti-inflammatory drugs through oral route in the reduction of postendodontic pain: A systematic review.Journal of conservative dentistry : JCDReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPosttreatment endodontic pain has been reported in 25%-40% of all endodontic patients. Effective management of endodontic pain represents a continuing challenge.
aimTo evaluate and compare the efficacy of preoperative single dose of nonsteroidal anti-inflammatory drug, piroxicam (20 mg), with two types of corticosteroid drugs - dexamethasone (4 mg) or deflazacort (30 mg) - for the prevention and control of postendodontic pain. MATERIALS AND
methodsA total of 132 volunteers selected for nonsurgical root canal therapy were randomly divided into the following four groups ( STATISTICAL ANALYSIS: The correlation between preoperative endodontic pain to postoperative pain and pair-wise comparison of four groups was evaluated by Kruskal-Wallis analysis of variance test followed by Mann-Whitney U-test.
resultsCompared to the placebo group, piroxicam, dexamethasone, and deflazacort resulted in a statistically significant reduction in postendodontic pain at 6, 12, and 24 h (
conclusionPreoperative single oral dose of piroxicam or dexamethasone or deflazacort is equally effective in controlling postendodontic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.