Evidence map›Paper›PMID 30820074›Full record

ReviewJournal of conservative dentistry : JCD

Saliva as a biomarker for dental caries: A systematic review.

Mithra N Hegde, Shruthi H Attavar, Nireeksha Shetty, Nidarsh D Hegde, Nishmitha N Hegde

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of conservative dentistry : JCD. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mithra N HegdeDepartment of Conservative Dentistry and Endodontics, A B Shetty Memorial Institute of Dental Science, NITTE University, Deralakatte, Mangalore, Karnataka, India.
Shruthi H AttavarDepartment of Conservative Dentistry and Endodontics, A B Shetty Memorial Institute of Dental Science, NITTE University, Deralakatte, Mangalore, Karnataka, India.
Nireeksha ShettyDepartment of Conservative Dentistry and Endodontics, A B Shetty Memorial Institute of Dental Science, NITTE University, Deralakatte, Mangalore, Karnataka, India.
Nidarsh D HegdeOral and Maxillofacial Surgeon, Dental Specialty Clinic, Kankanady, Mangalore, Karnataka, India.
Nishmitha N HegdeA B Shetty Memorial Institute of Dental Science, NITTE University, Deralakatte, Mangalore, Karnataka, India.
Nitte University · INK.S. Hegde Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe aim of the present review article is to establish a systematic review to describe the role of various salivary components such as pH, buffering capacity, proteins, electrolyte, antioxidant, enzymes, and minerals in occurrence and initiation of dental caries in participants with and without dental caries. METHODOLOGY: An electronic search was conducted in the PubMed, Scopus, Web of Science, and Google Scholar databases. The MESH terms (Medical Subject Headings) were "dental caries susceptibility," "caries risk assessment, "Salivary Biomarker," "saliva," "Proteins," "electrolytes," "biomarker," "Anti-oxidant's." The database search was limited to the studies published between 2008 and 2018 and only human studies were included. Furthermore, the STROBE criteria checklist was used to analyze the studies which had to be included in the systematic review.

resultsA total of 150 articles were retrieved through electronic database. After evaluating the title, abstract, and full text of these articles, only 11 were selected for the present systematic review. However, two articles were excluded because they were classified as high risk of bias according to the STROBE criteria. Out of 9 studies selected, 5 were classified as low-risk bias and 4 were classified as moderate-risk bias.

conclusionBased on the results of the systematic review, out of 11 studies, 7 found to have a statistically significant difference between individuals with and without caries experience. Hence, it can be concluded that there is an association between various components of saliva and dental caries.

Indexed as

Biomarkersdental cariessalivaSTROBE criteria

Identifiers

PMID30820074
PMCPMC6385571
OpenAlexW2937124277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.