Evidence map›Paper›PMID 30820047›Full record

SynthesisNature genetics2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf and 462 more

Erratum issued Registry-linked trialOpen access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01315639 (Plasma Abeta Peptides and the Risk of Alzheimer's Disease. Diagnostic Performance and Predictive and Prognostic Values of Measurements of Plasma Amyloid Peptides Concentrations for the Diagnosis of Alzheimer's Disease), which is not on this map. Cited by 1,928 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,928citing papers in PubMed, 4 pooled it
217.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01315639 nacompletednot on this map

Plasma Abeta Peptides and the Risk of Alzheimer's Disease. Diagnostic Performance and Predictive and Prognostic Values of Measurements of Plasma Amyloid Peptides Concentrations for the Diagnosis of Alzheimer's Disease

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2010 to 2018Enrolled1,067ConditionsAlzheimer's Disease, Mild Cognitive ImpairmentArmsbiomarkers, MRI and CSF
3 · Its place in the literature

Who cites it

1,928 citing papers in PubMed, 4 syntheses or guidelines pooled it, 3,124 citations in OpenAlex.

  1. Pooled it
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  15. Clusterin is enriched in plaque-associated astrocytes and localizes to synapses in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  16. Allele-specific expression in the brain links genetic risk and cortical thinning in psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  17. Article
  18. Article
  19. Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  20. Article

1,868 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

472 authors at 20 institutions in 20 countries.

Brian W KunkleJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu.ORCID http://orcid.org/0000-0002-9515-5157
Benjamin Grenier-BoleyInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Rebecca SimsDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Vincent DamotteInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Adam C NajDepartment of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Anne BolandCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Maria VronskayaDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Sven J van der LeeDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-1606-8643
Alexandre Amlie-WolfPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2073-1519
Céline BellenguezInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.ORCID http://orcid.org/0000-0002-1240-7874
Aura FrizattiDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Vincent ChourakiInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Eden R MartinJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Kristel SleegersNeurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-0283-2332
Nandini BadarinarayanDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Johanna JakobsdottirIcelandic Heart Association, Kopavogur, Iceland.
Kara L Hamilton-NelsonJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Sonia Moreno-GrauResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Robert OlasoCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Rachel RaybouldDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Yuning ChenDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7358-7055
Amanda B KuzmaPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Taniesha MorganDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Shahzad AhmadDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Badri N VardarajanTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Jacques EpelbaumUMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France.
Per HoffmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Merce BoadaResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Gary W BeechamJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Jean-Guillaume GarnierCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Denise HaroldSchool of Biotechnology, Dublin City University, Dublin, Ireland.
Annette L FitzpatrickDepartment of Family Medicine, University of Washington, Seattle, WA, USA.
Otto ValladaresPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Marie-Laure MoutetCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Amy GerrishDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Albert V SmithDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Liming QuPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Delphine BacqCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Nicola DenningDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Xueqiu JianBrown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
Yi ZhaoPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Maria Del ZompoSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Nick C FoxDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Seung-Hoan ChoiResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Ignacio MateoNeurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
Joseph T HughesDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Hieab H AdamsDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3687-2508
John MalamonPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Florentino Sanchez-GarciaDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Yogen PatelDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8509-148X
Beth A DombroskiPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Maria Candida Deniz NaranjoDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Makrina DaniilidouDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, WA, USA.
David WallonNormandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
James UphillDepartment of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
Thor AspelundIcelandic Heart Association, Kopavogur, Iceland.ORCID http://orcid.org/0000-0002-7998-5433
Laura B CantwellPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Fabienne GarziaCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Daniela GalimbertiFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.
Mariusz ButkiewiczInstitute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Bertrand FinCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Elio ScarpiniFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.
Chloe SarnowskiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Will S BushInstitute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-9729-6519
Stéphane MeslageCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Johannes KornhuberDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
Charles C WhiteProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Yuenjoo SongInstitute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Robert C BarberDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.ORCID http://orcid.org/0000-0001-6857-0286
Sebastiaan EngelborghsLaboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Sabrina SordonDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Dina VoijnovicDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Perrie M AdamsDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium.
Manuel MayhausDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
L Adrienne CupplesFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0003-0273-7965
Marilyn S AlbertDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Peter P De DeynLaboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-2228-2964
Wei GuDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Jayanadra J HimaliFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0003-1391-9481
Duane BeeklyNational Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
Alessio SquassinaSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0001-7415-7607
Annette M HartmannDepartment of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Adelina OrellanaResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Deborah BlackerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Eloy Rodriguez-RodriguezNeurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
Simon LovestoneDepartment of Psychiatry, University of Oxford, Oxford, UK.
Melissa E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
Rachelle S DoodyAlzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA.
Carmen Munoz-FernadezDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Rebecca SussamsDivision of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
Honghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3043-3942
Thomas J FairchildOffice of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA.
Yolanda A BenitoDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Clive HolmesDivision of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
Hata Karamujić-ČomićDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Matthew P FroschC.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA.
Hakan ThonbergTheme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.
Wolfgang MaierGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Gennady RoshchupkinDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3403-2313
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1842-8019
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-3423-2021
Amit KawaliaDepartment for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
Shuo LiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2331-2448
Ryan M HuebingerDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lena KilanderDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Susanne MoebusInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
Isabel HernándezResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
M Ilyas KambohDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
RoseMarie BrundinDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
James TurtonInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Mindy J KatzDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Letizia ConcariSection of Neuroscience, DIMEC-University of Parma, Parma, Italy.
Jenny LordInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Alexa S BeiserFramingham Heart Study, Framingham, MA, USA.
C Dirk KeeneDepartment of Pathology, University of Washington, Seattle, WA, USA.
Seppo HelisalmiInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Iwona KloszewskaElderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland.
Walter A KukullDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Anne Maria KoivistoInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Aoibhinn LynchMercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.
Lluís TarragaResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Annakaisa HaapasaloA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Brian LawlorMercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.
Thomas H MosleyDepartments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA.
Richard B LiptonDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Vincenzo SolfrizziInterdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy.
Michael GillMercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.ORCID http://orcid.org/0000-0003-0206-5337
W T LongstrethDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Thomas J MontineDepartment of Pathology, University of Washington, Seattle, WA, USA.
Vincenza FrisardiDepartment of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
Monica Diez-FairenFundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Vincent DeramecourtCHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
Ignacio AlvarezFundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.
Francesca SalaniDepartment of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Antonio CiaramellaDepartment of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Eric BoerwinkleSchool of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Eric M ReimanNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Nathalie FievetInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Joan S ReischDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Olivier HanonUniversity Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France.
Chiara CupidiRegional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
A G Andre UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Donald R RoyallDepartments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA.
Carole DufouilUniversity of Bordeaux, Inserm 1219, Bordeaux, France.
Raffaele Giovanni MalettaRegional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
Itziar de RojasResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Mary SanoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexis BriceInserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Roberta CecchettiSection of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Peter St George-HyslopCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Karen RitchieInserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.
Magda TsolakiDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID http://orcid.org/0000-0002-2072-8010
Debby W TsuangVA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.
Bruno DuboisInstitut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.
David CraigAgeing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Chuang-Kuo WuDepartments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA.
Hilkka SoininenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Despoina AvramidouDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Roger L AlbinDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Laura FratiglioniAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Antonia GermanouDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Liana G ApostolovaIndiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Lina KellerAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Maria KoutroumaniDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Steven E ArnoldDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Francesco PanzaDepartment of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
Olymbia GkatzimaDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Sanjay AsthanaGeriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.
Didier HannequinDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Patrice WhiteheadJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Craig S AtwoodDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0001-5040-1679
Paolo CaffarraAlzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
Harald HampelAXA Research Fund & Sorbonne University Chair, Paris, France.
Inés QuintelaGrupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain.
Ángel CarracedoGrupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain.
Lars LannfeltDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
David C RubinszteinCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-5002-5263
Lisa L BarnesDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Florence PasquierCHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.ORCID http://orcid.org/0000-0001-9880-9788
Lutz FrölichCentral Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
Sandra BarralTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Bernadette McGuinnessAgeing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Thomas G BeachCivin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA.
Janet A JohnstonAgeing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
James T BeckerDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-4425-4726
Peter PassmoreAgeing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Eileen H BigioDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jonathan M SchottDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0003-2059-024X
Thomas D BirdDepartment of Neurology, University of Washington, Seattle, WA, USA.
Jason D WarrenDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Michelle K LuptonDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7274-7299
James D BowenSwedish Medical Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4258-250X
Petra ProitsiDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Adam BoxerDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
John F PowellDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
James R BurkeDepartment of Neurology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-3408-7787
John S K KauweDepartments of Biology, Brigham Young University, Provo, UT, USA.
Jeffrey M BurnsUniversity of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA.
Michelangelo MancusoDepartment of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.ORCID http://orcid.org/0000-0003-2738-8562
Joseph D BuxbaumDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ubaldo BonuccelliDepartment of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
Nigel J CairnsDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Andrew McQuillinDivision of Psychiatry, University College London, London, UK.ORCID http://orcid.org/0000-0003-1567-2240
Chuanhai CaoUSF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
Gill LivingstonDivision of Psychiatry, University College London, London, UK.
Chris S CarlsonDepartment of Medicine, University of Wisconsin, Madison, WI, USA.
Nicholas J BassDivision of Psychiatry, University College London, London, UK.
Cynthia M CarlssonFred Hutchinson Cancer Research Center, Seattle, WA, USA.
John HardyDepartment of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
Regina M CarneyMental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA.
Jose BrasUK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Minerva M CarrasquilloDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Rita GuerreiroUK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Mariet AllenDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Helena C ChuiDepartment of Neurology, University of Southern California, Los Angeles, CA, USA.
Elizabeth FisherDepartment of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0003-2850-9936
Carlo MasulloDepartment of Neurology, Catholic University of Rome, Rome, Italy.
Elizabeth A CroccoDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Charles DeCarliDepartment of Neurology, University of California, Davis, Sacramento, CA, USA.
Gina BisceglioDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Malcolm DickInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Li MaDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Ranjan DuaraWien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA.
Neill R Graff-RadfordDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Denis A EvansRush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
Angela HodgesDepartment of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Kelley M FaberIndiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Martin SchererDepartment of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Kenneth B FallonDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Matthias RiemenschneiderDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
David W FardoSanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0002-7207-4696
Reinhard HeunDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Martin R FarlowDepartment of Neurology, Indiana University, Indianapolis, IN, USA.
Heike KölschDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Steven FerrisDepartment of Psychiatry, New York University, New York, NY, USA.
Markus LeberDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
Tatiana M ForoudIndiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Isabella HeuserDepartment of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.
Douglas R GalaskoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Ina GieglingDepartment of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Marla GearingDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
Michael HüllDepartment of Psychiatry, University of Freiburg, Freiburg, Germany.
Daniel H GeschwindNeurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA.
John R GilbertJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
John MorrisDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Robert C GreenDivision of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kevin MayoDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
John H GrowdonDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Thomas FeulnerDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Ronald L HamiltonDepartment of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-6802-1102
Lindy E HarrellDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Dmitriy DrichelCologne Center for Genomics, University of Cologne, Cologne, Germany.
Lawrence S HonigTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Thomas D CushionDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Matthew J HuentelmanNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Paul HollingworthDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Christine M HuletteDepartment of Pathology, Duke University, Durham, NC, USA.
Bradley T HymanDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Rachel MarshallDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Gail P JarvikDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Alun MeggyDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Erin AbnerSanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA.
Georgina E MenziesDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-6600-6507
Lee-Way JinUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Ganna LeonenkoDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Luis M RealUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
Gyungah R JunDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Clinton T BaldwinDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Detelina GrozevaDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Anna KarydasSwedish Medical Center, Seattle, WA, USA.
Giancarlo RussoFunctional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland.
Jeffrey A KayeDepartment of Neurology, Oregon Health &Science University, Portland, OR, USA.
Ronald KimDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Frank JessenGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Neil W KowallDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Bruno VellasInserm U558, University of Toulouse, Toulouse, France.
Joel H KramerDepartment of Neuropsychology, University of California San Francisco, San Francisco, CA, USA.
Emma VardyInstitute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
Frank M LaFerlaDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
James J LahDepartment of Neurology, Emory University, Atlanta, GA, USA.
Martin DichgansInstitute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.
James B LeverenzCleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA.
David MannDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Allan I LeveyDepartment of Neurology, Emory University, Atlanta, GA, USA.
Stuart Pickering-BrownDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID http://orcid.org/0000-0003-1561-6054
Andrew P LiebermanDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Norman KloppInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany.
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9268-810X
H-Erich WichmannHelmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany.
Constantine G LyketsosDepartment of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
Kevin MorganHuman Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-8217-2396
Daniel C MarsonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Kristelle BrownInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Frank MartiniukDepartment of Medicine-Pulmonary, New York University, New York, NY, USA.
Christopher MedwayInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Deborah C MashDepartment of Neurology, University of Miami, Miami, FL, USA.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Eliezer MasliahDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Nigel M HooperDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID http://orcid.org/0000-0002-5811-3484
Wayne C McCormickDepartment of Medicine, University of Washington, Seattle, WA, USA.
Antonio DanieleInstitute of Neurology, Catholic University of Sacred Hearth, Rome, Italy.
Susan M McCurrySchool of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA.
Anthony BayerInstitute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK.
Andrew N McDavidUSF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-6581-1213
John GallacherDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-2394-5299
Ann C McKeeDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Hendrik van den BusscheDepartment of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Marsel MesulamMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Carol BrayneCambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Bruce L MillerWeill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
Carol A MillerDepartment of Pathology, University of Southern California, Los Angeles, CA, USA.
Joshua W MillerDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA.
Ammar Al-ChalabiInstitute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.ORCID http://orcid.org/0000-0002-4924-7712
John C MorrisDepartment of Pathology and Immunology, Washington University, St. Louis, MO, USA.
Christopher E ShawInstitute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.
Amanda J MyersDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
Sid O'BryantDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
John M OlichneyDepartment of Neurology, University of California, Davis, Sacramento, CA, USA.
Victoria AlvarezMolecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
Joseph E ParisiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Andrew B SingletonMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Henry L PaulsonDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
John CollingeDepartment of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
William R PerryJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Simon MeadDepartment of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
Elaine PeskindDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
David H CribbsDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Martin RossorDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Aimee PierceDepartment of Neurology, University of California, Irvine, Irvine, CA, USA.
Natalie S RyanDepartment of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
Wayne W PoonInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-0625-3968
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Huntington PotterDepartment of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
Sandro SorbiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Joseph F QuinnDepartment of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Eleonora SacchinelliDepartment of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID http://orcid.org/0000-0002-7648-5126
Ashok RajUSF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
Gianfranco SpallettaLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Murray RaskindDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Carlo CaltagironeLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Paola BossùDepartment of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Maria Donata OrfeiLaboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Barry ReisbergDepartment of Psychiatry, New York University, New York, NY, USA.
Robert ClarkeOxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9802-8241
Christiane ReitzTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
A David SmithOxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
John M RingmanDepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA.
Donald WardenOxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
Erik D RobersonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-1810-9763
Gordon WilcockOxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
Ekaterina RogaevaTanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
Amalia Cecilia BruniRegional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
Howard J RosenDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Maura GalloRegional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
Roger N RosenbergDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yoav Ben-ShlomoPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Mark A SagerDepartment of Medicine, University of Wisconsin, Madison, WI, USA.
Patrizia MecocciSection of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Andrew J SaykinIndiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1376-8532
Pau PastorFundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7493-8777
Michael L CuccaroJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Jeffery M VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Julie A SchneiderDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Lori S SchneiderDepartment of Neurology, University of Southern California, Los Angeles, CA, USA.
Susan SliferJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
William W SeeleyDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Amanda G SmithUSF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
Joshua A SonnenDepartment of Pathology, University of Washington, Seattle, WA, USA.
Salvatore SpinaDepartment of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.
Robert A SternDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Russell H SwerdlowUniversity of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA.
Mitchell TangPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Rudolph E TanziDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7032-1454
John Q TrojanowskiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Juan C TroncosoDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Vivianna M Van DeerlinDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Linda J Van EldikSanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, KY, USA.
Harry V VintersDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Jean Paul VonsattelTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, NY, USA.
Sandra WeintraubMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kathleen A Welsh-BohmerDepartment of Neurology, Duke University, Durham, NC, USA.
Kirk C WilhelmsenDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jennifer WilliamsonTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Thomas S WingoDepartment of Neurology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7679-6282
Randall L WoltjerDepartment of Pathology, Oregon Health & Science University, Portland, OR, USA.
Clinton B WrightNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Chang-En YuDepartment of Medicine, University of Washington, Seattle, WA, USA.
Lei YuDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Yasaman SabaGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
Alberto PilottoGerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Maria J BullidoCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-6477-1117
Oliver PetersDepartment of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
David BennettDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Paola BoscoInstituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy.
Eliecer CotoMolecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
Virginia BoccardiSection of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Phil L De JagerCenter for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8057-2505
Alberto LleoCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
Nick WarnerSomerset Partnership NHS Trust, Somerset, UK.
Oscar L LopezDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Martin IngelssonDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
Panagiotis DeloukasThe Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.ORCID http://orcid.org/0000-0001-9251-070X
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0276-2899
Caroline GraffTheme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.
Rhian GwilliamThe Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
Alison M GoateDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-0576-2472
Pascual Sanchez-JuanNeurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
Patrick G KehoeUniversity of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK.
Najaf AminDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Nilifur Ertekin-TanerDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Claudine BerrInserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.ORCID http://orcid.org/0000-0001-5254-7655
Stéphanie DebetteInserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Seth LoveUniversity of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
Steven G YounkinDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Jean-Francois DartiguesMemory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France.
Chris CorcoranUtah State University, Logan, UT, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0001-7189-7917
Gael NicolasNormandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
Dominique CampionNormandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
JoAnn TschanzUtah State University, Logan, UT, USA.
Helena SchmidtGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jordi ClarimonCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
Ron MungerUtah State University, Logan, UT, USA.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.
Lindsay A FarrerDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Christine Van BroeckhovenNeurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-0183-7665
Michael C O'DonovanDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0001-7073-2379
Anita L DeStefanoDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Lesley JonesDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-3007-4612
Jonathan L HainesInstitute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Jean-Francois DeleuzeCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
Michael J OwenDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-4798-0862
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Richard MayeuxTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
Valentina Escott-PriceDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-1784-5483
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Alfredo RamirezDepartment for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-4991-763X
Li-San WangPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Agustin RuizResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Peter A HolmansDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Sudha SeshadriFramingham Heart Study, Framingham, MA, USA.
Julie WilliamsDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Phillippe AmouyelInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Gerard D SchellenbergPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Jean-Charles LambertInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr.ORCID http://orcid.org/0000-0003-0829-7817
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu.ORCID http://orcid.org/0000-0001-7283-8804
Alzheimer Disease Genetics Consortium (ADGC),
European Alzheimer’s Disease Initiative (EADI),
Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE),
Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES),
Boston University · USUniversity of Washington · USUniversity of Miami · USInserm · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRErasmus MC · NLKing's College London · GBUniversity of Bonn · DEUppsala University · SERush University Medical Center · USUniversity of California, Irvine · USUK Dementia Research Institute · GBUniversity of California, San Francisco · USUniversity of Eastern Finland · FIUniversity of Southern California · USAristotle University of Thessaloniki · GREmory University · USHarvard University · USUniversity of Nottingham · GBInstituto de Salud Carlos III · ES

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUI, HELENA CHANG · 1985 to 2019
$41.0M
Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
Medical Research Council G0300429Medical Research Council G0500289Medical Research Council G0600237Medical Research Council G0600974Medical Research Council G0701075Medical Research Council G0801418Medical Research Council G0900421Medical Research Council G0900688Medical Research Council G0901254Medical Research Council G0902227Medical Research Council G9810900Medical Research Council MC_PC_14095Medical Research Council MC_PC_18025Medical Research Council MC_U123160657Medical Research Council MC_UU_00024/1Medical Research Council MC_UU_00024/9Medical Research Council MR/K013041/1Medical Research Council MR/K01417X/1Medical Research Council MR/L010305/1Medical Research Council MR/L021803/1Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Medical Research Council MR/L501517/1Medical Research Council MR/L501529/1Medical Research Council MR/L501542/1Medical Research Council MR/M009076/1Medical Research Council MR/M024784/1Medical Research Council MR/N012453/1Medical Research Council MR/N026004/1Medical Research Council MR/R024804/1Motor Neurone Disease Association ALCHALABI-DOBSON/APR14/829-791Motor Neurone Disease Association SHAW/NOV14/985-797NCATS NIH HHS UL1 TR001414NCATS NIH HHS UL1 TR002369NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NIA NIH HHS K25 AG055620NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG017266NIA NIH HHS P30 AG044271NIA NIH HHS P30 AG053760NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG018454NIA NIH HHS R01 AG041232NIA NIH HHS R01 AG054060NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG061796NIA NIH HHS RF1 AG015473NIA NIH HHS RF1 AG051504NIA NIH HHS RF1 AG054023NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG032438NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG056270NINDS NIH HHS R01 NS017950Parkinson's UK G-0907Wellcome Trust 203249/Z/16/Z
6 · The paper itself

Abstract

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimer's disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10

Indexed as

AgedAlzheimer DiseaseAmyloid beta-PeptidesCase-Control StudiesFemaleGenetic LociGenetic Predisposition to DiseaseGenetic TestingGenome-Wide Association StudyHaplotypesHumansImmunityLipid MetabolismLipidsMaletau ProteinsAmyloid beta-PeptidesLipidstau Proteins

Identifiers

PMID30820047
PMCPMC6463297
OpenAlexW2916749909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.