ArticleProceedings of the National Academy of Sciences of the United States of America2019
Encoding biological recognition in a bicomponent cell-membrane mimic.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Pepticombisomes: Biomimetic Vesicles Crafted From Recombinant Supercharged Polypeptides with Uniformly Distributed Side-Chains.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The 2025 motile active matter roadmap.Journal of physics. Condensed matter : an Institute of Physics journal · 2025Review
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- Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review.Pharmaceutics · 2023Review
- Effects of sugar concentration on the electroporation, size distribution and average size of charged giant unilamellar vesicles.European biophysics journal : EBJ · 2022Article
- Ionic Combisomes: A New Class of Biomimetic Vesicles to Fuse with Life.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Oligosaccharide Presentation Modulates the Molecular Recognition of Glycolipids by Galectins on Membrane Surfaces.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Enhanced Concanavalin A Binding to Preorganized Mannose Nanoarrays in Glycodendrimersomes Revealed Multivalent Interactions.Angewandte Chemie (International ed. in English) · 2021Article
- Dynamic membranes: the multiple roles of P4 and P5 ATPases.Plant physiology · 2021Article
- Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Bioactive Virus-Mimicking Nanovesicles From Dendrimersomes: A Novel Approach to Understanding SARS-CoV-2 Host-Interactions to Better Design Therapeutics.Frontiers in molecular biosciences · 2020Article
- Comprehensive Profiling of Surface Gangliosides Extracted from Various Cell Lines by LC-MS/MS.Cells · 2019Article
- Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Effects of linker and liposome anchoring on lactose-functionalized glycomacromolecules as multivalent ligands for binding galectin-3.RSC advances · 2019Article
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Authors and funding
20 authors.
Funding
Abstract
Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same periodic and quasiperiodic arrays were subsequently found in block copolymers, surfactants, lipids, glycolipids, and other complex molecules. Here we report the discovery of lamellar and hexagonal periodic arrays on the surface of vesicles generated from sequence-defined bicomponent monodisperse oligomers containing lipid and glycolipid mimics. These vesicles, known as glycodendrimersomes, act as cell-membrane mimics with hierarchical morphologies resembling bicomponent rafts. These nanosegregated morphologies diminish sugar-sugar interactions enabling stronger binding to sugar-binding proteins than densely packed arrangements of sugars. Importantly, this provides a mechanism to encode the reactivity of sugars via their interaction with sugar-binding proteins. The observed sugar phase-separated hierarchical arrays with lamellar and hexagonal morphologies that encode biological recognition are among the most complex architectures yet discovered in soft matter. The enhanced reactivity of the sugar displays likely has applications in material science and nanomedicine, with potential to evolve into related technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.