ArticleProceedings of the National Academy of Sciences of the United States of America2019
Theory of mechanochemical patterning in biphasic biological tissues.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mechanics of compression-driven morphogenesis.Development (Cambridge, England) · 2026Review
- Tissue rigidity phase transition shapes morphogen gradients.Nature cell biology · 2026Article
- Adhesion strength, cell packing density and cell surface buckling in pericellular matrix-mediated tissue cohesion.Development (Cambridge, England) · 2025Article
- Morphogen gradients are regulated by porous media characteristics of the developing tissue.Development (Cambridge, England) · 2025Article
- A computational pipeline for spatial mechano-transcriptomics.Nature methods · 2025Article
- Mechanochemical dynamics of collective cells and hierarchical topological defects in multicellular lumens.Science advances · 2024Article
- Physical interactions in non-ideal fluids promote Turing patterns.Journal of the Royal Society, Interface · 2023Article
- A self-generated Toddler gradient guides mesodermal cell migration.Science advances · 2022Article
- Interplay between cell height variations and planar pulsations in epithelial monolayers.The European physical journal. E, Soft matter · 2022Article
- Modeling mechanochemical pattern formation in elastic sheets of biological matter.The European physical journal. E, Soft matter · 2021Article
- From embryos to embryoids: How external signals and self-organization drive embryonic development.Stem cell reports · 2021Review
- Roadmap for the multiscale coupling of biochemical and mechanical signals during development.Physical biology · 2021Review
- Article
- Interactions at engineered graft-tissue interfaces: A review.APL bioengineering · 2020Review
- Pattern formation mechanisms of self-organizing reaction-diffusion systems.Developmental biology · 2020Review
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Authors and funding
3 authors.
Funding
Abstract
The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a minimal model combining tissue mechanics with morphogen turnover and transport to explore routes to patterning. Our active description couples morphogen reaction and diffusion, which impact cell differentiation and tissue mechanics, to a two-phase poroelastic rheology, where one tissue phase consists of a poroelastic cell network and the other one of a permeating extracellular fluid, which provides a feedback by actively transporting morphogens. While this model encompasses previous theories approximating tissues to inert monophasic media, such as Turing's reaction-diffusion model, it overcomes some of their key limitations permitting pattern formation via any two-species biochemical kinetics due to mechanically induced cross-diffusion flows. Moreover, we describe a qualitatively different advection-driven Keller-Segel instability which allows for the formation of patterns with a single morphogen and whose fundamental mode pattern robustly scales with tissue size. We discuss the potential relevance of these findings for tissue morphogenesis.
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