Evidence map›Paper›PMID 30819616›Full record

ArticleRedox biology2019

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4

C M Moshfegh, C W Collins, V Gunda, A Vasanthakumar, J Z Cao, P K Singh, L A Godley, Adam J Case

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Tumor-associated CD8Frontiers in immunology · 2024
    Article
  12. S100a9 Protects Against the Effects of Repeated Social Defeat Stress.Biological psychiatry global open science · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. T-lymphocyte tyrosine hydroxylase regulates TBrain, behavior, and immunity · 2022
    Article
  17. Article
  18. How metabolism bridles cytotoxic CD8Trends in immunology · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

C M MoshfeghDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, United States.
C W CollinsDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, United States.
V GundaThe Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, United States.
A VasanthakumarSection of Hematology/Oncology, Department of Medicine, The University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, United States.
J Z CaoSection of Hematology/Oncology, Department of Medicine, The University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, United States.
P K SinghThe Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, United States.
L A GodleySection of Hematology/Oncology, Department of Medicine, The University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, United States.
Adam J CaseDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address: adam.case@unmc.edu.
University of Nebraska Medical Center · USUniversity of Chicago Medicine Comprehensive Cancer CenterUniversity of Chicago · US

Funding

Redox Regulation of T-lymphocytes in Sympathoexcitation-associated HypertensionR00HL123471 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CASE, ADAM J · 2016 to 2018
$765k
NHLBI NIH HHS R00 HL123471
6 · The paper itself

Abstract

While the role of mitochondrial metabolism in controlling T-lymphocyte activation and function is becoming more clear, the specifics of how mitochondrial redox signaling contributes to T-lymphocyte regulation remains elusive. Here, we examined the global effects of elevated mitochondrial superoxide (O

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytokinesDNA MethylationEpigenesis, GeneticHydrogen PeroxideLymphocyte ActivationMaleMiceMice, Inbred C57BLMitochondriaOxidation-ReductionOxidative StressSignal TransductionSuperoxide DismutaseCytokinesHydrogen PeroxideSuperoxide DismutaseSuperoxidesAdaptive immunityApoptosisCytokinesHydroxymethylationImmuneManganese superoxide dismutaseMetabolismMethylationOxidative stressProliferationRedox

Identifiers

PMID30819616
PMCPMC6859572
OpenAlexW2916135400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.