ArticleNeuron2019
The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.
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In one paragraph
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 1 of them a synthesis that pooled it.
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128citing papers in PubMed, 1 pooled it
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Who cites it
128 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy evaluation of personalized coaptation in neurotization for motor deficit after peripheral nerve injury: A systematic review and meta-analysis.Brain and behavior · 2020Pooled it
- Article
- Extrinsic Regulation of Optic Nerve Axon Regeneration in the Adult Central Nervous System.Cells · 2026Review
- Piezo1 channel: structure, mechanogating mechanism, functions, diseases and therapeutic strategy.Molecular biomedicine · 2026Review
- Aging-Related Changes in the Injury Response of the Peripheral Nervous System.Neuroscience bulletin · 2026Review
- Article
- The mechanotransduction channel Piezo2 refines axonal projections to the accessory optic system and regulates the optokinetic reflex.bioRxiv : the preprint server for biology · 2026Article
- A comparative study assessing neural recording quality and inflammatory tissue response between stiff and flexible microelectrode arrays.Biomaterials · 2026Article
- An implantable mechano-electro cascade platform synchronizes neuro-muscle repair.Nature communications · 2026Article
- The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment.Orthopaedic surgery · 2026Review
- Mechanotransduction in the Brain: Soliton Theory, Piezo Receptors and MR Elastography in Headache Pathophysiology.Brain and behavior · 2026Review
- Tentonin 3 regulates the proliferation and migration of neural stem cells during embryonic brain development.BMC biology · 2026Article
- Lipid Regulation of Mechanosensitive Ion Channels.International journal of molecular sciences · 2026Review
- Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions.Cells · 2026Review
- Impaired PIEZO1 function drives uterine hypercontractility in adenomyosis-associated dysmenorrhea.Human reproduction open · 2026Article
- The role of ECM-PIEZO1-axis-mediated mechanosensation in the central nervous system.Frontiers in neurology · 2026Review
- Piezo1 as a mechanical checkpoint in T cell immunotherapy for solid tumors.Frontiers in pharmacology · 2026Review
- Targeting Piezo1/2 ion channels for modulation of the lymphatic system: mechanisms, applications, and therapeutic prospects.Burns & trauma · 2026Review
- Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration.PLoS genetics · 2025Article
- Magnetically guided neurite outgrowth modulated by PIEZO1 in hiPSC-derived retinal ganglion cells.Materials today. Bio · 2025Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Yuanquan SongRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: songy2@email.chop.edu.
Dan LiRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Olivia FarrellyDepartment of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Leann MilesThe Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Feng LiRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sung Eun KimDepartments of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Tsz Y LoRaymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Fei WangDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Tun LiDepartments of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Katherine L Thompson-PeerDepartments of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
Jiaxin GongDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Swetha E MurthyDepartment of Neuroscience, The Scripps Research Institute, Howard Hughes Medical Institute, La Jolla, CA 92037, USA.
Bertrand CosteDepartment of Neuroscience, The Scripps Research Institute, Howard Hughes Medical Institute, La Jolla, CA 92037, USA.
Nikita YakubovichDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Ardem PatapoutianDepartment of Neuroscience, The Scripps Research Institute, Howard Hughes Medical Institute, La Jolla, CA 92037, USA.
Yang XiangDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Panteleimon RompolasDepartment of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lily Yeh JanDepartments of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Yuh Nung JanDepartments of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: yuhnung.jan@ucsf.edu.
Funding
Dendrite morphogenesis, function and regenerationR35NS097227 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, YUH NUNG · 2017 to 2024
$5.1MGraduate Training in Developmental BiologyT32HD083185 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato, Foteini Mourkioti · 2015 to 2026
$4.0MGenetic Dissection of Dendrite DevelopmentR37NS040929 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, YUH NUNG · 2010 to 2016
$2.5MTargeting Atr to promote regeneration and functional recovery after neural injuryR01NS107392 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SONG, YUANQUAN · 2018 to 2022
$1.9MMolecular Mechanisms of nociceptor sensitizationR01NS089787 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI XIANG, YANG · 2015 to 2019
$1.8MMechanistic studies of novel factors regulating axon regeneration in the PNS/CNSR00NS088211 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SONG, YUANQUAN · 2016 to 2018
$728kMechanisms of Dendrite Regeneration after InjuryK99NS097627 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMPSON-PEER, KATHERINE LOUISE · 2016 to 2017
$198kMechanistic studies of novel factors regulating axon regeneration in the PNS/CNSK99NS088211 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SONG, YUANQUAN · 2014 to 2015
$190kNICHD NIH HHS T32 HD083185NINDS NIH HHS K99 NS088211NINDS NIH HHS K99 NS097627NINDS NIH HHS R00 NS088211NINDS NIH HHS R01 NS089787NINDS NIH HHS R01 NS107392NINDS NIH HHS R35 NS097227NINDS NIH HHS R37 NS040929
Abstract
Neurons exhibit a limited ability of repair. Given that mechanical forces affect neuronal outgrowth, it is important to investigate whether mechanosensitive ion channels may regulate axon regeneration. Here, we show that DmPiezo, a Ca
Indexed as
AnimalsAxonsCalciumCyclic GMP-Dependent Protein KinasesDrosophila melanogasterDrosophila ProteinsGrowth ConesIon ChannelsMechanotransduction, CellularMiceMice, KnockoutNerve RegenerationNitric Oxide SynthaseRegenerationSensory Receptor CellsCalciumCyclic GMP-Dependent Protein KinasesDrosophila Proteinsfor protein, DrosophilaIon ChannelsNitric Oxide SynthasePiezo1 protein, mousePiezo protein, Drosophilaaxon regenerationcorneal sensory nervedendritic arborization neuronsDrosophilaion channelsmammalian injury modelmechanosensitivenitric oxide synthasePiezo
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.