Evidence map›Paper›PMID 30819348›Full record

ReviewPediatric clinics of North America2019

Gastroesophageal Reflux Disease in the Neonatal Intensive Care Unit Infant: Who Needs to Be Treated and What Approach Is Beneficial?

Ish K Gulati, Sudarshan R Jadcherla

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric clinics of North America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Efficacy and accuracy of the transillumination-guided gastric tube placement in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Observational
  4. Review
  5. Article
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  7. Review
  8. Review
  9. Review
  10. Feeding characteristics of healthy infants without reported feeding impairments throughout the first month of life.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Bronchopulmonary dysplasia: what are its links to COPD?Therapeutic advances in respiratory disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ish K GulatiInnovative Research Program in Neonatal Feeding Disorders; The Neonatal and Infant Feeding Disorders Program, Nationwide Children's Hospital, Columbus, OH, USA.
Sudarshan R JadcherlaInnovative Research Program in Neonatal Feeding Disorders; The Neonatal and Infant Feeding Disorders Program, Nationwide Children's Hospital, Columbus, OH, USA; Division of Neonatology, Department of Pediatrics, Center for Perinatal Research, WB 5211, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, 575 Children's Cross Roads, Columbus, OH 43215, USA; Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Center for Perinatal Research, WB 5211, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, 575 Children's Cross Roads, Columbus, OH 43215, USA. Electronic address: Sudarshan.Jadcherla@nationwidechildrens.org.

Funding

Pathophysiology of Aerodigestive Reflexes in InfantsR01DK068158 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI JADCHERLA, SUDARSHAN R · 2006 to 2016
$3.7M
NIDDK NIH HHS R01 DK068158
6 · The paper itself

Abstract

Gastroesophageal reflux (GER) and GER disease (GERD) pertaining to infants in the neonatal intensive care unit (NICU) are reviewed, based on research in this specific population. The developmental biology of the gastroesophageal junction, physiology of GER, and pathophysiology of GERD in this setting are summarized, and risk factors for GER and GERD identified. The epidemiology, economic burden, and controversies surrounding GERD in NICU infants are addressed, and an approach to GER and GERD in these patients formulated. Recent advancements in individual assessment of GER and GERD in the NICU infant are examined, and evidence-based guidelines for their adoption provided.

Indexed as

Esophageal Sphincter, LowerGastroesophageal RefluxHumansInfant, NewbornIntensive Care Units, NeonatalManometryRisk FactorsGERGERDNeonateNICUPreterm

Identifiers

PMID30819348
PMCPMC6400306

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.