Trial reportJournal of neuroengineering and rehabilitation2019
Novel gait training alters functional brain connectivity during walking in chronic stroke patients: a randomized controlled pilot trial.
Trial report in Journal of neuroengineering and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Effects of treadmill training combined with transcranial direct current stimulation on mobility, motor performance, balance function, and other brain-related outcomes in stroke survivors: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Combined Use of EMG and EEG Techniques for Neuromotor Assessment in Rehabilitative Applications: A Systematic Review.Sensors (Basel, Switzerland) · 2021Pooled it
- Brain activity during real-time walking and with walking interventions after stroke: a systematic review.Journal of neuroengineering and rehabilitation · 2021Pooled it
- Effects of Robotic Neurorehabilitation on Body Representation in Individuals with Stroke: A Preliminary Study Focusing on an EEG-Based Approach.Brain topography · 2021Trial
- Robotic Rehabilitation in Spinal Cord Injury: A Pilot Study on End-Effectors and Neurophysiological Outcomes.Annals of biomedical engineering · 2021Trial
- Article
- Neuromechanical Predictors of Clinical Scores of Balance and Functional Mobility in Chronic Stroke Survivors - A Machine Learning Approach.medRxiv : the preprint server for health sciences · 2025Article
- Resting-State Functional Connectivity of Sensorimotor and Default Mode Networks and Lower Limb Performance in Chronic Stroke: A Cross-Sectional Study.Brain and behavior · 2025Article
- Electrophysiological Approaches to Understanding Brain-Muscle Interactions During Gait: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- Time synchronization between parietal-frontocentral connectivity with MRCP and gait in post-stroke bipedal tasks.Journal of neuroengineering and rehabilitation · 2024Article
- Measuring Neuroplasticity in Response to Cardiovascular Exercise in People With Stroke: A Critical Perspective.Neurorehabilitation and neural repair · 2024Article
- Targeting CNS Neural Mechanisms of Gait in Stroke Neurorehabilitation.Brain sciences · 2022Article
- Distinct gait dimensions are modulated by physical activity in Parkinson's disease patients.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Association Between Temporal Asymmetry and Muscle Synergy During Walking With Rhythmic Auditory Cueing in Survivors of Stroke Living With Impairments.Archives of rehabilitation research and clinical translation · 2022Article
- Finding the Way to Improve Motor Recovery of Patients with Spinal Cord Lesions: A Case-Control Pilot Study on a Novel Neuromodulation Approach.Brain sciences · 2022Article
- Neuroplasticity after upper-extremity rehabilitation therapy with sensory stimulation in chronic stroke survivors.Brain communications · 2022Article
- Increased gait variability during robot-assisted walking is accompanied by increased sensorimotor brain activity in healthy people.Journal of neuroengineering and rehabilitation · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA recent study has demonstrated that a turning-based treadmill program yields greater improvements in gait speed and temporal symmetry than regular treadmill training in chronic stroke patients. However, it remains unknown how this novel and challenging gait training shapes the cortico-cortical network and cortico-spinal network during walking in chronic stroke patients. The purpose of this study was to examine how a novel type of gait training, which is an unfamiliar but effective task for people with chronic stroke, enhances brain reorganization.
methodsSubjects in the experimental and control groups received 30 min of turning-based treadmill training and regular treadmill training, respectively. Cortico-cortical connectivity and cortico-muscular connectivity during walking and gait performance were assessed before and after completing the 12-session training.
resultsEighteen subjects (n = 9 per group) with a mean age of 52.5 ± 9.7 years and an overground walking speed of 0.61 ± 0.26 m/s consented and participated in this study. There were significant group by time interactions for gait speed, temporal gait symmetry, and cortico-cortical connectivity as well as cortico-muscular connectivity in walk-related frequency (24-40 Hz) over the frontal-central-parietal areas. Compared with the regular treadmill training, the turning-based treadmill training resulted in greater improvements in these measures. Moreover, the increases in cortico-cortical connectivity and cortico-muscular connectivity while walking were associated with improvements in temporal gait symmetry.
conclusionsOur findings suggest this novel turning-based treadmill training is effective for enhancing brain functional reorganization underlying cortico-cortical and corticomuscular mechanisms and thus may result in gait improvement in people with chronic stroke.
trial registrationACTRN12617000190303 . Registered 3 February 2017, retrospectively registered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.